Acetazolamide

Generic Name: Acetazolamide

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₄H_₆N_₄O_₃S_₂

CAS Number: 59-66-5

Unique Ingredient Identifier: O3FX965V0I

Background: One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of...

Indication: For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions: Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication

Associated Therapies: Urine alkalinization therapy

Clinical Trials

Controlled Hyperventilation as Prophylaxis for Acute Mountain Sickness

Not Applicable

Conditions: Altitude Sickness

Interventions: Behavioral: Voluntary ventilatory response
Drug: Acetazolamide

First Posted Date: 2016-11-23

Last Posted Date: 2016-11-23

Lead Sponsor: Hospital del Trabajador de Santiago

Target Recruit Count: 30

Registration Number: NCT02972411

Locations: 🇨🇱
110 Sports and health center, Santiago, Chile

Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)

Phase 2

Terminated

Conditions: Neurocysticercosis

Interventions: Drug: Dexamethasone
Drug: Acetazolamide

First Posted Date: 2016-10-26

Last Posted Date: 2022-06-22

Lead Sponsor: Universidad Peruana Cayetano Heredia

Target Recruit Count: 4

Registration Number: NCT02945527

Locations: 🇵🇪
Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru

Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome

Phase 2

Terminated

Conditions: Landau-Kleffner Syndrome
Status Epilepticus, Electrographic

Interventions: Drug: Diazepam
Drug: Acetazolamide

First Posted Date: 2016-09-16

Last Posted Date: 2020-06-11

Lead Sponsor: Mayo Clinic

Target Recruit Count: 3

Registration Number: NCT02904265

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Acetazolamide to Prevent Post Operative CSF Leak

Phase 2

Withdrawn

Conditions: Cerebrospinal Fluid Leak

Interventions: Drug: Acetazolamide

First Posted Date: 2016-09-15

Last Posted Date: 2020-04-21

Lead Sponsor: University of Miami

Registration Number: NCT02902133

Cerebrovascular Reserve Measurements in Sickle Cell Disease

Conditions: Sickle Cell Disease

Interventions: Drug: Acetazolamide

First Posted Date: 2016-07-06

Last Posted Date: 2016-07-06

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 60

Registration Number: NCT02824406

Locations: 🇳🇱
Academic Medical Center, Amsterdam, Netherlands

Evaluation of the Effect of Acetazolamide, Mannitol and N-acetylcysteine on Cisplatin-Induced Nephrotoxicity

Phase 2

Completed

Conditions: Cisplatin Nephrotoxicity

Interventions: Drug: Acetazolamide
Drug: Mannitol
Drug: Acetylcysteine
Drug: saline
Drug: Cisplatin

First Posted Date: 2016-05-04

Last Posted Date: 2017-01-24

Lead Sponsor: Ain Shams University

Target Recruit Count: 52

Registration Number: NCT02760901

AZ, MZ, and the Pulmonary System Response to Hypoxia

Phase 4

Completed

Conditions: Altitude Sickness
Hypertension, Pulmonary

Interventions: Drug: Placebo
Drug: Acetazolamide
Drug: Methazolamide

First Posted Date: 2016-05-03

Last Posted Date: 2016-10-19

Lead Sponsor: University of British Columbia

Target Recruit Count: 14

Registration Number: NCT02760121

Locations: 🇨🇦
University of British Columbia, Kelowna, British Columbia, Canada

Muscle Fatigue and Carbonic Anhydrase Inhibitors

Phase 4

Completed

Conditions: Hypoxia

Interventions: Other: Placebo
Drug: Acetazolamide
Drug: Methazolamide

First Posted Date: 2016-05-02

Last Posted Date: 2018-09-25

Lead Sponsor: University of British Columbia

Target Recruit Count: 13

Registration Number: NCT02758470

Locations: 🇨🇦
University of British Columbia, Kelowna, British Columbia, Canada

Chronic Clinical Effect of Acetazolamide

Phase 2

Completed

Conditions: Hypertension, Pulmonary

Interventions: Drug: Acetazolamide
Drug: Placebo

First Posted Date: 2016-04-28

Last Posted Date: 2020-12-19

Lead Sponsor: University of Zurich

Target Recruit Count: 24

Registration Number: NCT02755298

Locations: 🇨🇭
University Hospital Zurich, Zurich, Switzerland

Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

Phase 2

Completed

Conditions: Hypertension, Pulmonary

Interventions: Drug: Placebo
Drug: Acetazolamide

First Posted Date: 2016-04-28

Last Posted Date: 2019-08-13

Lead Sponsor: University of Zurich

Target Recruit Count: 33

Registration Number: NCT02755259

Locations: 🇨🇭
University Hospital Zurich, Zurich, Switzerland

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