Cilostazol

Generic Name: Cilostazol

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₇N_₅O_₂

CAS Number: 73963-72-1

Unique Ingredient Identifier: N7Z035406B

Background: Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reduci...

Indication: Indicated for the alleviation of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).

Associated Conditions: Intermittent Claudication

Associated Therapies: -

Clinical Trials

The Headache Inducing Effects of Cilostazol on Migraine Patients

Not Applicable

Completed

Conditions: Migraine

Interventions: Drug: Cilostazol
Drug: Placebo

First Posted Date: 2013-04-29

Last Posted Date: 2014-06-06

Lead Sponsor: Danish Headache Center

Target Recruit Count: 14

Registration Number: NCT01841827

Locations: 🇩🇰
Danish Headache Center & Department of Neurology, Copenhagen, Glostrup, Denmark

The Effect of Genetic Polymorphism on Interactions of Clopidogrel and Cilostazol in Healthy Volunteers

Not Applicable

Completed

Conditions: Interaction

Interventions: Drug: Clopidogrel
Drug: Cilostazol
Drug: Clopidogrel/Cilostazol

First Posted Date: 2011-11-30

Last Posted Date: 2013-06-03

Lead Sponsor: Inje University

Target Recruit Count: 28

Registration Number: NCT01482117

Cilostazol Augmentation Study in Dementia

Phase 4

Completed

Conditions: Alzheimer's Dementia

Interventions: Drug: Cilostazol
Drug: Placebo

First Posted Date: 2011-08-04

Last Posted Date: 2014-05-13

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 46

Registration Number: NCT01409564

Locations: 🇰🇷
SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of

A Study on the Effect of Cilostazol in Patients With Chronic Tinnitus

Not Applicable

Completed

Conditions: Tinnitus

Interventions: Drug: Placebo
Drug: Cilostazol

First Posted Date: 2011-06-22

Last Posted Date: 2014-05-22

Lead Sponsor: Jong Woo Chung

Target Recruit Count: 50

Registration Number: NCT01378650

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Drug-Eluting Stenting Followed by Cilostazol tREAtment Reduces SErious Adverse Cardiac Events (DECREASE-PCI)

Phase 4

Terminated

Conditions: Coronary Artery Disease

Interventions: Drug: Placebo
Drug: Cilostazol

First Posted Date: 2011-05-03

Last Posted Date: 2015-11-16

Lead Sponsor: Seung-Jung Park

Target Recruit Count: 402

Registration Number: NCT01346865

Locations: 🇰🇷
Sejong General Hospital, Bucheon, Korea, Republic of
🇰🇷
Chungnam National University Hospital, Daejeon, Korea, Republic of
🇰🇷
Soon Chun Hyang University Hospital Cheonan, Cheonan, Korea, Republic of

and more 9 locations

Effect of Probucol and/or Cilostazol on Mean IMT in Patients With Coronary Heart dIsease

Phase 4

Completed

Conditions: Hyperlipidemias

Interventions: Drug: HMG-CoA Reductase Inhibitor
Drug: Probucol
Drug: Cilostazol

First Posted Date: 2011-02-08

Last Posted Date: 2019-09-20

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 342

Registration Number: NCT01291641

Locations: 🇰🇷
Dong-A Medical Center, Seogu, Busan, Korea, Republic of
🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
🇰🇷
Boramae Medical Center, Seoul, Korea, Republic of

and more 2 locations

Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation

Phase 4

Completed

Conditions: Coronary Artery Disease

Interventions: Drug: Cilostazol
Drug: Aspirin
Drug: Clopidogrel

First Posted Date: 2010-09-01

Last Posted Date: 2016-11-15

Lead Sponsor: Yonsei University

Target Recruit Count: 630

Registration Number: NCT01192724

Locations: 🇰🇷
Wonju Christian Hospital, Wonju, Gangwon, Korea, Republic of

The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study)

Phase 4

Completed

Conditions: Ischemic Stroke

Interventions: Other: placebo
Drug: Cilostazol

First Posted Date: 2010-08-26

Last Posted Date: 2013-10-07

Lead Sponsor: China Medical University Hospital

Target Recruit Count: 801

Registration Number: NCT01188824

Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines

Phase 4

Completed

Conditions: Polyneuropathy

Interventions: Drug: Cilostazol

First Posted Date: 2010-02-26

Last Posted Date: 2010-02-26

Lead Sponsor: Otsuka Pharmaceutical, Inc., Philippines

Target Recruit Count: 47

Registration Number: NCT01076478

Locations: 🇵🇭
University of Santo Tomas Hospital, Manila, Philippines

PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage

Phase 4

Conditions: Brain Ischemia
Intracranial Hemorrhages

Interventions: Drug: Cilostazol
Drug: Probucol
Drug: Aspirin
Drug: placebo of aspirin
Drug: placebo of cilostazol
Device: ankle-brachial index (ABI)
Device: intima-medial thickness (IMT)
Device: new asymptomatic brain hemorrhage
Device: new ischemic lesions on follow-up FLAIR images

First Posted Date: 2009-11-13

Last Posted Date: 2015-12-24

Lead Sponsor: Asan Medical Center

Target Recruit Count: 1600

Registration Number: NCT01013532

Locations: 🇰🇷
Korea University Ansan Hospital, Ansan, Gyeonggi-do, Korea, Republic of
🇰🇷
Hanyang University Medical Center, Seoul, Korea, Republic of
🇰🇷
Wonju Christian Hospital, Wonju, Gangwon-do, Korea, Republic of

and more 68 locations

Drug Development Updates

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