Overview
Hypromellose, or hydroxypropyl methylcellulose (HPMC) , is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and binder in the process of granulation and in modified release formulations . It is a commonly used as a delivery component in oral pharmaceutical products that provides the release of a drug in a controlled fashion, effectively increasing the duration of release of a drug to prolong its therapeutic effects . Hypromellose is also found in eye drops as a lubricant .
Indication
Used as an ophthalmic protectant and lubricant, in artificial tears, and as a diagnostic aid (contact lens procedures; gonioscopy).
Associated Conditions
- Dry Eyes
- Ocular Discomfort
- Ocular Irritation
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/07/03 | Not Applicable | Not yet recruiting | Center for Sight Las Vegas | ||
2025/03/20 | Phase 4 | Recruiting | |||
2025/01/08 | Phase 4 | Recruiting | |||
2024/04/23 | Phase 1 | Not yet recruiting | |||
2024/01/24 | Phase 4 | Completed | Chang Gung Memorial Hospital | ||
2024/01/23 | Phase 4 | Completed | Scripps Poway Eyecare and Optometry | ||
2024/01/03 | Phase 2 | Completed | |||
2023/01/30 | Phase 4 | Completed | |||
2022/10/26 | Phase 4 | Completed | Tauber Eye Center | ||
2021/04/30 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Hypromellose Eye Drops | 国药准字H20103788 | 化学药品 | 眼用制剂 | 5/9/2022 | |
| Hypromellose Eye Drops | 国药准字H20067905 | 化学药品 | 滴眼剂 | 3/25/2020 | |
| Hypromellose Eye Drops | 国药准字H20053470 | 化学药品 | 眼用制剂 | 4/30/2020 | |
| Hypromellose Eye Drops | 国药准字H20073657 | 化学药品 | 眼用制剂 | 5/16/2023 | |
| Hypromellose Eye Drops | 国药准字H20045427 | 化学药品 | 眼用制剂(滴眼液) | 8/12/2020 | |
| Hypromellose Eye Drops | 国药准字H20093895 | 化学药品 | 眼用制剂 | 11/4/2020 | |
| Hypromellose Eye Drops | 国药准字H20066274 | 化学药品 | 眼用制剂 | 5/31/2021 | |
| Hypromellose Eye Drops | 国药准字H20074116 | 化学药品 | 眼用制剂 | 1/9/2023 | |
| Hypromellose Eye Drops | 国药准字H20064221 | 化学药品 | 眼用制剂 | 8/26/2021 | |
| Hypromellose Eye Drops | 国药准字H20043417 | 化学药品 | 滴眼剂 | 8/13/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| LOSTEAR EYE DROPS 0.3% W/V | N/A | N/A | N/A | 7/6/2016 | |
| GENTEAL EYE GEL | N/A | alcon hong kong ltd | N/A | N/A | 2/16/2004 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MediHerb Gotu Kola Complex (Export Only) | 389071 | Medicine | A | 5/25/2022 |
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