Doxapram

Overview

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.

Title	Posted	Study ID	Phase	Status	Sponsor
Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial	2025/06/15	NCT07022704	N/A	Recruiting	Cairo University
Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension	2024/09/05	NCT06585163	Phase 1	Not yet recruiting	Quivive Pharma, Inc.
Doxapram Therapy in Preterm Infants (DOXA Trial)	2020/06/12	NCT04430790	Phase 3	Recruiting	Erasmus Medical Center
The Effect of Doxapram Versus Theophylline on Diaphragmatic Function	2019/03/28	NCT03894189	Not Applicable	UNKNOWN	Beni-Suef University
The Effect and Mechanism of Respiratory Stimulant Doxapram on Facilitating Emergence	2016/06/30	NCT02820025	Not Applicable	UNKNOWN	General Hospital of Ningxia Medical University
Doxapram as an Additive to Propofol Sedation in Sedation for ERCP	2014/06/24	NCT02171910	Phase 4	Completed	Helsinki University Central Hospital
Aminophylline and Cognitive Function After Sevoflurane Anaesthesia	2009/12/01	NCT01022151	Phase 2	Completed	King Faisal University
Staccato Alprazolam in Panic Attack	2007/05/23	NCT00477451	Phase 2	Completed	Alexza Pharmaceuticals, Inc.
Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants	2006/10/19	NCT00389909	Phase 4	Completed	Jean Michel Hascoet

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Dopram	Hikma Pharmaceuticals USA Inc.	0641-6018	INTRAVENOUS	20 mg in 1 mL	2/19/2021
DOXAPRAM HYDROCHLORIDE	HF Acquisition Co LLC, DBA HealthFirst	51662-1404	INTRAVENOUS	20 mg in 1 mL	2/22/2020

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
Doxapram Hydrochloride Injection	西安汉丰药业有限责任公司	国药准字H20054743	化学药品	注射剂	6/5/2020
Doxapram Hydrochloride Injection	上海禾丰制药有限公司	国药准字H20033303	化学药品	注射剂	10/9/2020
Doxapram Hydrochloride Injection	扬子江药业集团南京海陵药业有限公司	国药准字H20056609	化学药品	注射剂	5/11/2020
Doxapram Hydrochloride Injection	晋城海斯制药有限公司	国药准字H20093692	化学药品	注射剂	6/4/2024
Doxapram Hydrochloride Injection	河南辅仁怀庆堂制药有限公司	国药准字H20068166	化学药品	注射剂	8/14/2020
Doxapram Hydrochloride Injection	江苏恩华药业股份有限公司	国药准字H32022989	化学药品	注射剂	7/14/2020
Doxapram Hydrochloride for Injection	江苏九旭药业有限公司	国药准字H20051761	化学药品	注射剂	7/23/2020
Doxapram Hydrochloride for Injection	浙江佐力药业股份有限公司	国药准字H20080379	化学药品	注射剂	1/5/2023
Doxapram Hydrochloride for Injection	吉林敖东洮南药业股份有限公司	国药准字H20052657	化学药品	注射剂	4/28/2020
Doxapram Hydrochloride for Injection	陕西博森生物制药股份集团有限公司	国药准字H20060165	化学药品	注射剂	11/22/2022

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.