A Comprehensive Monograph on Lactiplantibacillus plantarum IS-10506: Mechanisms, Clinical Evidence, and Therapeutic Potential

Executive Summary

Lactiplantibacillus plantarum IS-10506 is a novel probiotic strain with a substantial and growing body of scientific evidence supporting its therapeutic potential across a range of clinical conditions. Isolated from 'dadih', a traditional Indonesian fermented buffalo milk, this strain has demonstrated a robust safety profile and significant efficacy rooted in its potent immunomodulatory and epithelial barrier-enhancing properties.[1] Its primary mechanisms of action involve the systemic rebalancing of T-helper cell responses, characterized by the suppression of pro-inflammatory Th2 and Th17 pathways and the promotion of Th1 and regulatory T-cell (Treg) functions.[3] This is coupled with the fortification of mucosal barriers, evidenced by increased expression of tight junction proteins in both the intestinal and respiratory tracts and enhanced production of secretory IgA (sIgA).[5]