Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Study to Evaluate the Response Rate to Therapy With Docetaxel and Cisplatin in Unresectable Locally Advanced Squamous Cell Carcinoma of Head and Neck

Phase 2

Completed

Conditions: Squamous Cell Carcinoma of Head and Neck

Interventions: Drug: Cisplatin
Drug: DOCETAXEL XRP6976
Drug: Dexamethasone

First Posted Date: 2014-02-13

Last Posted Date: 2015-10-08

Lead Sponsor: Sanofi

Target Recruit Count: 35

Registration Number: NCT02061631

MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple Myeloma

Phase 1

Completed

Conditions: Multiple Myeloma
Kahler Disease
Plasma-Cell Myeloma
Myelomatosis

Interventions: Drug: Panobinostat
Drug: Dexamethasone
Drug: MLN9708

First Posted Date: 2014-02-07

Last Posted Date: 2019-12-11

Lead Sponsor: Jason Valent

Target Recruit Count: 16

Registration Number: NCT02057640

Locations: 🇺🇸
University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

A Rollover Study for Subjects That Have Participated in an Astellas Sponsored Linsitinib Trial

Phase 2

Completed

Conditions: Advanced Solid Tumors

Interventions: Drug: linsitinib
Drug: paclitaxel
Drug: erlotinib
Drug: Bortezomib
Drug: Dexamethasone

First Posted Date: 2014-02-07

Last Posted Date: 2024-11-20

Lead Sponsor: Astellas Pharma Global Development, Inc.

Target Recruit Count: 13

Registration Number: NCT02057380

Locations: 🇺🇸
Site US10004, La Jolla, California, United States
🇺🇸
Site US10006, Tampa, Florida, United States
🇺🇸
Site US10002, Baltimore, Maryland, United States

and more 9 locations

Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children

Not Applicable

Conditions: Stridor

Interventions: Drug: Budesonide
Drug: Dexamethasone

First Posted Date: 2014-02-06

Last Posted Date: 2014-02-06

Lead Sponsor: Hospital Israelita Albert Einstein

Target Recruit Count: 70

Registration Number: NCT02056379

Locations: 🇧🇷
Instituto Israelita de Ensino e Pesquisa Albert Einstein 's (IIEP), São Paulo, Brazil

Use of Dexamethasone in Uterine Artery Embolization

Not Applicable

Completed

Conditions: Adenomyosis
Uterine Myoma

Interventions: Drug: Normal saline
Drug: Dexamethasone

First Posted Date: 2014-02-06

Last Posted Date: 2015-04-17

Lead Sponsor: Severance Hospital

Target Recruit Count: 64

Registration Number: NCT02056717

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Phase II Multicenter, Open-label, Single Arm Clinical Study of Pomalidomide and dexamethasonE and Cyclophosphamide

Phase 2

Completed

Conditions: Relapsed or Refractory Multiple Myeloma

Interventions: Drug: Imnovid (pomalidomide)
Drug: Dexamethasone
Drug: Endoxan (Cyclophosphamide)

First Posted Date: 2014-01-28

Last Posted Date: 2017-10-30

Lead Sponsor: University Hospital Tuebingen

Target Recruit Count: 60

Registration Number: NCT02046915

Locations: 🇩🇪
University Hospital, Tuebingen, Germany

Phase 2 Trial of Carfilzomib for Metastatic Castration-resistant Prostate Cancer Following Treatment

Phase 2

Completed

Conditions: Metastatic Castration-resistant Prostate Cancer

Interventions: Drug: Carfilzomib
Drug: Dexamethasone
Drug: Acyclovir

First Posted Date: 2014-01-28

Last Posted Date: 2018-12-19

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 28

Registration Number: NCT02047253

Locations: 🇺🇸
University of Tulane, New Orleans, Louisiana, United States
🇺🇸
Birmingham VA Medical Center, Birmingham, Alabama, United States
🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States

and more 1 locations