Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Efficiency Study for Acute Radiation-induced and Chemotherapy-induced Pulmonary Fibrosis With Bevasizumab
- First Posted Date
- 2013-08-07
- Last Posted Date
- 2023-03-29
- Lead Sponsor
- Qingdao Central Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT01917877
- Locations
- 🇨🇳
Qingdao Central Hospital, Qingdao, Shandong, China
Maintenance Therapy With Subcutaneous Bortezomib
- First Posted Date
- 2013-08-01
- Last Posted Date
- 2023-12-13
- Lead Sponsor
- Stichting European Myeloma Network
- Target Recruit Count
- 63
- Registration Number
- NCT01913730
- Locations
- 🇮🇹
Irccs Crob, Rionero in Vulture, Potenza, Italy
The Efficacy and Safety of Palonosetron in Preventing the Gastrointestinal Reactions Induced by 3-day Highly Emetogenic Chemotherapy
- Conditions
- Cancer
- Interventions
- First Posted Date
- 2013-07-29
- Last Posted Date
- 2015-12-04
- Lead Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
- Target Recruit Count
- 92
- Registration Number
- NCT01909856
- Locations
- 🇨🇳
Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
S1304, Carfilzomib and Dexamethasone for Treating Patients With Relapsed or Refractory Myeloma
- Conditions
- Recurrent Plasma Cell MyelomaRefractory Plasma Cell Myeloma
- Interventions
- First Posted Date
- 2013-07-19
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- SWOG Cancer Research Network
- Target Recruit Count
- 143
- Registration Number
- NCT01903811
- Locations
- 🇺🇸
Illinois CancerCare-Carthage, Carthage, Illinois, United States
🇺🇸Illinois CancerCare-Princeton, Princeton, Illinois, United States
🇺🇸John Muir Medical Center-Concord Campus, Concord, California, United States
Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies
- Conditions
- Non-Hodgkin LymphomaAcute LeukemiaHodgkin Lymphoma
- Interventions
- First Posted Date
- 2013-07-16
- Last Posted Date
- 2017-03-22
- Lead Sponsor
- St. Jude Children's Research Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT01900509
- Locations
- 🇺🇸
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients
- Conditions
- Relapsed and/or Relapsed-refractory Multiple Myeloma
- Interventions
- First Posted Date
- 2013-07-12
- Last Posted Date
- 2020-10-23
- Lead Sponsor
- Oncopeptides AB
- Target Recruit Count
- 75
- Registration Number
- NCT01897714
- Locations
- 🇮🇹
Turin Hospital Myeloma Unit, Turin, Italy
🇩🇰Vejle Hospital, Vejle, Denmark
🇸🇪Sahlgrenska Hospital, Gothenburg, Sweden
PH III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Previously Untreated Multiple Myeloma (ELO 1 Substudy)
- Conditions
- Newly Diagnosed, Previously Untreated Multiple Myeloma
- Interventions
- First Posted Date
- 2013-07-03
- Last Posted Date
- 2021-07-01
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 23
- Registration Number
- NCT01891643
- Locations
- 🇺🇸
Crescent City Research Consortium, LLC, Marrero, Louisiana, United States
🇺🇸Illinois Cancercare, Pc, Peoria, Illinois, United States
🇺🇸Memorial Cancer Institute, Hollywood, Florida, United States
Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemia
- Conditions
- Mixed Phenotype Acute LeukemiaRelapsed or Refractory Acute Lymphoblastic LeukemiaRelapsed or Refractory Lymphoblastic Lymphoma
- Interventions
- First Posted Date
- 2013-06-27
- Last Posted Date
- 2020-01-22
- Lead Sponsor
- Ehab L Atallah
- Target Recruit Count
- 5
- Registration Number
- NCT01887587
- Locations
- 🇺🇸
Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Evaluation of Efficacy and Safety of Epidural Steroid Injection Using Dexamethasone or Betamethasone
- Conditions
- Back PainNeck Pain
- Interventions
- First Posted Date
- 2013-06-25
- Last Posted Date
- 2016-03-30
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 600
- Registration Number
- NCT01885481
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Oprozomib and Dexamethasone,in Combination With Lenalidomide or Oral Cyclophosphamide to Treat Newly Diagnosed Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2013-06-20
- Last Posted Date
- 2022-11-14
- Lead Sponsor
- Amgen
- Target Recruit Count
- 22
- Registration Number
- NCT01881789
- Locations
- 🇺🇸
David Geffen School of Medicine at UCLA, Los Angeles, California, United States
🇺🇸Providence St. Joseph's Hospital, Burbank, California, United States
🇺🇸Clearview Cancer Institute, Huntsville, Alabama, United States
Drug Development Updates
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