Acamprosate
- Generic Name
- Acamprosate
- Brand Names
- Campral
- Drug Type
- Small Molecule
- Chemical Formula
- C5H11NO4S
- CAS Number
- 77337-76-9
- Unique Ingredient Identifier
- N4K14YGM3J
- Background
Alcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and economic consequences resulting from accidents, violence, incarceration, decreased productivity, and increased healthcare spending.
Acamprosate, also known by the brand name Campral, is a drug used for the maintenance of alcohol abstinence. It is a structural analogue of the neurotransmitter γ-aminobutyric acid (GABA). Acamprosate is the first medication specifically formulated for the maintenance of alcohol abstinence in ethanol-dependent patients after alcohol detoxification, unlike naltrexone and disulfiram. It was first approved by the FDA in 2004 and initially marketed by Forest Laboratories.
- Indication
Acamprosate is indicated for the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation. It is also indicated for the maintenance of alcohol abstinence in patients who have undergone alcohol detoxification. This drug should be used with a psychosocial support program providing adequate support.
- Associated Conditions
- Alcohol Abstinence, Alcohol Dependency
Study of Acamprosate in Driving Under the Influence (DUI) Court Participants
- First Posted Date
- 2007-01-23
- Last Posted Date
- 2012-07-27
- Lead Sponsor
- University of Oklahoma
- Target Recruit Count
- 4
- Registration Number
- NCT00425711
- Locations
- 🇺🇸
The University of Oklahoma, Tulsa, Tulsa, Oklahoma, United States
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
- First Posted Date
- 2006-10-09
- Last Posted Date
- 2020-07-10
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 60
- Registration Number
- NCT00385268
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic
- First Posted Date
- 2006-09-27
- Last Posted Date
- 2017-05-17
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 100
- Registration Number
- NCT00381043
- Locations
- 🇺🇸
Center for Addiction and Behavioral Health Research University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States
🇺🇸UNC Family Medicine Center, Chapel Hill, North Carolina, United States
Acamprosate Initiated During Alcohol Detoxification
- First Posted Date
- 2006-08-04
- Last Posted Date
- 2017-01-11
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 40
- Registration Number
- NCT00360594
- Locations
- 🇺🇸
Treatment Research Center, Philadelphia, Pennsylvania, United States
Open Label Trial of Acamprosate in Bipolar Alcoholics
- Conditions
- Alcohol DependenceBipolar Disorder
- First Posted Date
- 2006-05-26
- Last Posted Date
- 2008-09-19
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 9
- Registration Number
- NCT00330486
- Locations
- 🇺🇸
Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, United States
Acamprosate in Alcoholics With Comorbid Anxiety or Depression
- Conditions
- Generalized Anxiety DisorderAlcohol DependenceMajor DepressionSocial Anxiety Disorder
- Interventions
- First Posted Date
- 2006-05-26
- Last Posted Date
- 2015-04-13
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 90
- Registration Number
- NCT00330174
- Locations
- 🇺🇸
Columbia University College of Physicians & Surgeons, New York, New York, United States
🇺🇸Behavioral Health Services of Pickens County, Pickens, South Carolina, United States
🇺🇸McLean Hospital, Belmont, Massachusetts, United States
Individually Adapted Therapy of Alcoholism
- First Posted Date
- 2006-04-21
- Last Posted Date
- 2008-06-27
- Lead Sponsor
- Central Institute of Mental Health, Mannheim
- Target Recruit Count
- 435
- Registration Number
- NCT00317031
- Locations
- 🇩🇪
Department of Psychiatry, University of Freiburg, Freiburg, BW, Germany
🇩🇪Department of Psychiatry, University of Tübingen, Tuebingen, BW, Germany
🇩🇪Department of Psychiatry, University of Regensburg, Regensburg, Bayern, Germany
Study of Acamprosate to Prevent Alcohol Relapse in Criminal Justice Supervisees
- First Posted Date
- 2005-11-07
- Last Posted Date
- 2016-05-11
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 26
- Registration Number
- NCT00249379
- Locations
- 🇺🇸
Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
Integrative Therapy in Alcoholism
- Conditions
- Alcoholism
- Interventions
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2008-01-30
- Lead Sponsor
- Heinrich-Heine University, Duesseldorf
- Target Recruit Count
- 371
- Registration Number
- NCT00159107
- Locations
- 🇩🇪
Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany, Düsseldorf, North Rhine-Westfalia, Germany
Trial for the Treatment of Alcohol Dependence
- Conditions
- Alcoholism
- First Posted Date
- 2005-07-18
- Last Posted Date
- 2005-07-18
- Lead Sponsor
- University of Sydney
- Target Recruit Count
- 200
- Registration Number
- NCT00120601
- Locations
- 🇦🇺
Drug Health Services, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Drug Development Updates
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