MedPath

Siremadlin

Generic Name
Siremadlin
Drug Type
Small Molecule
Chemical Formula
C26H24Cl2N6O4
CAS Number
1448867-41-1
Unique Ingredient Identifier
0282IF4JC8

A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat

Phase 1
Completed
Conditions
Colorectal Cancer, Non-small Cell Lung Carcinoma (Adenocarcinoma), Triple Negative Breast Cancer, Renal Cell Carcinoma
Interventions
First Posted Date
2016-09-07
Last Posted Date
2023-01-11
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
298
Registration Number
NCT02890069
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Huntsman Cancer Institute, Salt Lake City, Utah, United States

๐Ÿ‡ฌ๐Ÿ‡ง

Novartis Investigative Site, Oxford, United Kingdom

๐Ÿ‡บ๐Ÿ‡ธ

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 7 locations

Study of Safety and Efficacy of HDM201 in Combination With LEE011 in Patients With Liposarcoma

Phase 1
Completed
Conditions
Liposarcoma
Interventions
First Posted Date
2015-01-21
Last Posted Date
2020-12-09
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
74
Registration Number
NCT02343172
Locations
๐Ÿ‡จ๐Ÿ‡ณ

Novartis Investigative Site, Taipei, Taiwan

Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt

Phase 1
Completed
Conditions
Advanced Solid and Hematological TP53wt Tumors
Interventions
Drug: ancillary treatment
First Posted Date
2014-05-21
Last Posted Date
2021-05-21
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
208
Registration Number
NCT02143635
Locations
๐Ÿ‡จ๐Ÿ‡ณ

Novartis Investigative Site, Taipei, Taiwan ROC, Taiwan

๐Ÿ‡บ๐Ÿ‡ธ

Dana Farber Cancer Institute SC-6, Boston, Massachusetts, United States

๐Ÿ‡บ๐Ÿ‡ธ

Memorial Sloan Kettering Onc. Dep, New York, New York, United States

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