Arsenic trioxide

Generic Name: Arsenic trioxide

Brand Names: Trisenox, Arsenic trioxide Accord, Arsenic trioxide Mylan, Arsenic trioxide medac

Drug Type: Small Molecule

Chemical Formula: As_₂O_₃

CAS Number: 1327-53-3

Unique Ingredient Identifier: S7V92P67HO

Background: Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

Indication: For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression

Associated Conditions: Acute Promyelocytic Leukemia, Refractory Acute Promyelocytic Leukemia, Relapsed Acute Promyelocytic Leukemia

Clinical Trials

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4 months ago

• Wildfire smoke contains complex pollutants including asbestos, chemicals, and toxic gases, potentially causing both immediate irritation and serious long-term health complications including permanent lung damage and cancer. • People with pre-existing respiratory conditions, young children, elderly individuals, and those with compromised immune systems face heightened risks from wildfire smoke exposure. • Health experts recommend using appropriate protective equipment, including N100/R100/P100 respirators for asbestos protection, and avoiding direct contact with debris and ash during cleanup efforts.

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