Dronabinol

Generic Name
Dronabinol
Brand Names
Marinol, Sativex, Syndros
Drug Type
Small Molecule
Chemical Formula
C21H30O2
CAS Number
1972-08-3
Unique Ingredient Identifier
7J8897W37S
Background

Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased ...

Indication

Dronabinol is indicated for the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.

Associated Conditions
Anorexia, Chemotherapy-Induced Nausea and Vomiting
Associated Therapies
-
Clinical Trials
Related News

THC Effects on Glucose in Type 2 Diabetes

Phase 1
Not yet recruiting
Conditions
Type 2 Diabetes
Interventions
Drug: THC
Drug: Placebo
First Posted Date
2022-04-11
Last Posted Date
2023-11-07
Lead Sponsor
University of California, San Diego
Target Recruit Count
30
Registration Number
NCT05322213
Locations
🇺🇸

UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California, United States

Reducing the Harmful Effects of Cannabis Use: Finding the Optimal CBD:THC Ratio

Not Applicable
Completed
Conditions
Cannabis Use
Interventions
Drug: THC
Drug: Cannabidiol
First Posted Date
2021-12-27
Last Posted Date
2021-12-27
Lead Sponsor
King's College London
Target Recruit Count
46
Registration Number
NCT05170217
Locations
🇬🇧

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Evaluation of Oral THC and CBD in Men and Women

First Posted Date
2021-10-05
Last Posted Date
2024-12-10
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
22
Registration Number
NCT05067387
Locations
🇺🇸

University of California, Los Angeles, Los Angeles, California, United States

Safety and Efficacy of Oral Cannabis in Chronic Spine Pain

Phase 3
Not yet recruiting
Conditions
Back Pain
Neck Pain
Interventions
Drug: THC/CBD
Drug: THC
Drug: Placebo
First Posted Date
2021-09-22
Last Posted Date
2023-01-10
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
157
Registration Number
NCT05052541
Locations
🇺🇸

University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories

Not Applicable
Recruiting
Conditions
Intrusive Memories
Interventions
Drug: Dronabinol
Drug: Placebo
First Posted Date
2021-05-04
Last Posted Date
2024-02-13
Lead Sponsor
Charite University, Berlin, Germany
Target Recruit Count
291
Registration Number
NCT04871269
Locations
🇩🇪

Charité - Universitätsmedizin Berlin, Berlin-Steglitz, Berlin, Germany

The Pharmacokinetics and Pharmacodynamics of Hemp-based Topical Cannabinoid Products

Phase 1
Completed
Conditions
Cannabis
Drug Effect
Interventions
Drug: CBD
Drug: Placebo
Drug: THC
First Posted Date
2021-02-05
Last Posted Date
2023-03-10
Lead Sponsor
Johns Hopkins University
Target Recruit Count
47
Registration Number
NCT04741477
Locations
🇺🇸

Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Does Cannabidiol Attenuate the Acute Effects of ∆9-tetrahydrocannabinol Intoxication in Individuals Diagnosed With Schizophrenia? A Double-blind, Randomised, Placebo-controlled Experimental Study

First Posted Date
2020-10-28
Last Posted Date
2023-08-18
Lead Sponsor
King's College London
Target Recruit Count
36
Registration Number
NCT04605393
Locations
🇬🇧

South London and Maudsley NHS Foundation Trust, London, United Kingdom

Reward and Drug Effects on Mood and Brain Response

Early Phase 1
Recruiting
Conditions
Cannabis Use
Healthy
Interventions
Drug: Placebo oral capsule
Drug: THC
First Posted Date
2020-08-13
Last Posted Date
2024-05-01
Lead Sponsor
University of Illinois at Chicago
Target Recruit Count
80
Registration Number
NCT04512365
Locations
🇺🇸

University of Illinois at Chicago, Chicago, Illinois, United States

Effects of Pregnancy-associated Hormones on THC Metabolism in Women

Phase 4
Active, not recruiting
Conditions
Pregnancy Related
Cannabis Use
Interventions
Drug: Dronabinol
First Posted Date
2020-05-05
Last Posted Date
2024-08-19
Lead Sponsor
University of Washington
Target Recruit Count
12
Registration Number
NCT04374773
Locations
🇺🇸

Nina Isoherranen, Seattle, Washington, United States

A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty

Phase 3
Recruiting
Conditions
Osteoarthritis, Knee
Interventions
Other: Placebo
Drug: Dronabinol
First Posted Date
2020-03-06
Last Posted Date
2023-01-10
Lead Sponsor
Colorado Joint Replacement
Target Recruit Count
460
Registration Number
NCT04298528
Locations
🇺🇸

Colorado Joint Replacement, Denver, Colorado, United States

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy