Dronabinol
- Generic Name
- Dronabinol
- Brand Names
- Marinol, Sativex, Syndros
- Drug Type
- Small Molecule
- Chemical Formula
- C21H30O2
- CAS Number
- 1972-08-3
- Unique Ingredient Identifier
- 7J8897W37S
- Background
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased ...
- Indication
Dronabinol is indicated for the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.
- Associated Conditions
- Anorexia, Chemotherapy-Induced Nausea and Vomiting
- Associated Therapies
- -
A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking
- First Posted Date
- 2016-11-10
- Last Posted Date
- 2019-10-02
- Lead Sponsor
- Battelle Memorial Institute
- Target Recruit Count
- 9
- Registration Number
- NCT02961309
- Locations
- 🇺🇸
Battelle Memorial Institute, Baltimore, Maryland, United States
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
- First Posted Date
- 2016-06-23
- Last Posted Date
- 2024-08-13
- Lead Sponsor
- Yale University
- Target Recruit Count
- 40
- Registration Number
- NCT02811510
- Locations
- 🇺🇸
Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, West Haven, Connecticut, United States
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
- First Posted Date
- 2016-05-24
- Last Posted Date
- 2024-08-13
- Lead Sponsor
- Yale University
- Target Recruit Count
- 100
- Registration Number
- NCT02781519
- Locations
- 🇺🇸
Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, West Haven, Connecticut, United States
The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia
- Conditions
- Interventions
- First Posted Date
- 2015-11-20
- Last Posted Date
- 2019-06-13
- Lead Sponsor
- NYU Langone Health
- Registration Number
- NCT02608931
- Locations
- 🇺🇸
NYU Medical Center, New York, New York, United States
Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain
- First Posted Date
- 2015-10-06
- Last Posted Date
- 2019-09-26
- Lead Sponsor
- Temple University
- Registration Number
- NCT02569073
- Locations
- 🇺🇸
Temple University Hospital, Philadelphia, Pennsylvania, United States
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study
- Conditions
- Interventions
- First Posted Date
- 2015-07-08
- Last Posted Date
- 2024-01-24
- Lead Sponsor
- Central Institute of Mental Health, Mannheim
- Target Recruit Count
- 60
- Registration Number
- NCT02492074
- Locations
- 🇩🇪
Central Institute of Mental Health, Mannheim, BW, Germany
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids
- Conditions
- Interventions
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2015-08-17
- Lead Sponsor
- Central Institute of Mental Health, Mannheim
- Target Recruit Count
- 60
- Registration Number
- NCT02487381
- Locations
- 🇩🇪
Central Institute of Mental Health, Mannheim, BW, Germany
Individual Differences in the Response to Drugs
- Conditions
- Interventions
- First Posted Date
- 2015-06-30
- Last Posted Date
- 2016-11-29
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 28
- Registration Number
- NCT02485158
Cannabinoid Control of Fear Extinction Neural Circuits in Humans
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2015-08-25
- Lead Sponsor
- University of Illinois at Chicago
- Target Recruit Count
- 85
- Registration Number
- NCT02472847
Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain
- Conditions
- Interventions
- First Posted Date
- 2015-06-02
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 131
- Registration Number
- NCT02460692
- Locations
- 🇺🇸
UC Center for Medicinal Cannabis Research, UC San Diego, San Diego, California, United States
Drug Development Updates
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