Repotrectinib

Generic Name
Repotrectinib
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C18H18FN5O2
CAS Number
1802220-02-5
Unique Ingredient Identifier
08O3FQ4UNP
Indication

用于ROS1阳性的局部晚期或转移性非小细胞肺癌(NSCLC)成人患者。

Associated Conditions
-
Associated Therapies
-

Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-08-13
Last Posted Date
2024-08-13
Lead Sponsor
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Target Recruit Count
30
Registration Number
NCT06552234
Locations
🇫🇷

CH Aix-en-Provence, Aix-en-Provence, Bouches Du Rhône, France

🇫🇷

CHU Bordeaux, Bordeaux, France

🇫🇷

Centre François Baclesse, Caen, France

and more 17 locations

A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants

Phase 1
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-07-10
Last Posted Date
2024-07-10
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
32
Registration Number
NCT06493409
Locations
🇺🇸

Fortrea - Daytona Beach, Daytona Beach, Florida, United States

A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment

Phase 1
Recruiting
Conditions
Interventions
First Posted Date
2024-04-08
Last Posted Date
2024-07-11
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
24
Registration Number
NCT06352528
Locations
🇺🇸

Orlando Clinical Research Center, Orlando, Florida, United States

🇺🇸

Local Institution - 0005, Orlando, Florida, United States

🇺🇸

Local Institution - 0006, Miami Lakes, Florida, United States

and more 3 locations

REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-03-18
Last Posted Date
2024-10-24
Lead Sponsor
MedSIR
Target Recruit Count
20
Registration Number
NCT06315010

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

First Posted Date
2023-11-20
Last Posted Date
2024-12-11
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
230
Registration Number
NCT06140836
Locations
🇮🇳

Grant Medical Foundation - Ruby Hall Clinic, Pune, Maharashtra, India

🇺🇸

Local Institution - 0136, Augusta, Georgia, United States

🇺🇸

Local Institution - 0221, Des Moines, Iowa, United States

and more 141 locations

Expanded Access for Repotrectinib

First Posted Date
2023-07-03
Last Posted Date
2023-07-03
Lead Sponsor
Bristol-Myers Squibb
Registration Number
NCT05926232

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

First Posted Date
2023-04-25
Last Posted Date
2024-10-31
Lead Sponsor
Turning Point Therapeutics, Inc.
Target Recruit Count
12
Registration Number
NCT05828303
Locations
🇪🇸

Local Institution - 2138, Madrid, M, Spain

🇺🇸

Local Institution - 2102, Denver, Colorado, United States

🇺🇸

Gabrail Cancer Center Research, Canton, Ohio, United States

and more 36 locations

A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors

First Posted Date
2021-10-08
Last Posted Date
2024-04-02
Lead Sponsor
Turning Point Therapeutics, Inc.
Target Recruit Count
9
Registration Number
NCT05071183
Locations
🇺🇸

Local Institution - 2107, Houston, Texas, United States

🇺🇸

Local Institution - 2102, Virginia Beach, Virginia, United States

🇺🇸

Local Institution - 2101, California City, California, United States

and more 3 locations

A Study of Repotrectinib in Combination with Chemotherapy in Children and Young Adults with Solid Tumor Cancer

First Posted Date
2021-08-13
Last Posted Date
2024-10-03
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
50
Registration Number
NCT05004116
Locations
🇺🇸

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States

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