Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted ...
Study on C57BL/6 IFN-γ knockout mice treated with KDU731 showed reduced parasite shedding. Oral soft drug strategy aimed to maximize intestinal exposure while minimizing systemic exposure. Compounds 1 and EDI048, with metabolically labile spots, were tested for efficacy and systemic exposure. EDI048 demonstrated dose-dependent reduction in oocyst shedding.
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Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted ...
Study on C57BL/6 IFN-γ knockout mice treated with KDU731 showed reduced parasite shedding. Oral soft drug strategy aimed to maximize intestinal exposure while minimizing systemic exposure. Compounds 1 and EDI048, with metabolically labile spots, were tested for efficacy and systemic exposure. EDI048 demonstrated dose-dependent reduction in oocyst shedding.