Half-dose glucarpidase as efficient rescue for toxic methotrexate ...
Half-dose glucarpidase (mean 25 U/kg) effectively reduced toxic MTX plasma concentrations by ≥97.7% in patients with HDMTX-associated acute kidney injury, making MTX levels manageable with intensified folinic acid rescue. This suggests lower glucarpidase doses may be sufficient, offering significant cost savings.
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Half-dose glucarpidase as efficient rescue for toxic methotrexate ...
Half-dose glucarpidase (mean 25 U/kg) effectively reduced toxic MTX plasma concentrations by ≥97.7% in patients with HDMTX-associated acute kidney injury, making MTX levels manageable with intensified folinic acid rescue. This suggests lower glucarpidase doses may be sufficient, offering significant cost savings.