CSF Proteomics Hints at How ApoE4 Promotes AD, and How a Drug Hinders It - Alzforum
A study published in Science Translational Medicine identifies 34 protein modules in cerebrospinal fluid (CSF) linked to Alzheimer’s disease (AD), including those involved in autophagy, ubiquitination, and glycolysis. Proteins related to oxidative stress, mitochondrial function, and neddylation were tied to ApoE4. In serum, these modules predicted AD up to two decades in advance. A clinical trial showed atomoxetine, a norepinephrine reuptake inhibitor, could mitigate some AD-associated pathways, particularly glycolysis.
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A study published in Science Translational Medicine identifies 34 protein modules in cerebrospinal fluid (CSF) linked to Alzheimer’s disease (AD), including those involved in autophagy, ubiquitination, and glycolysis. Proteins related to oxidative stress, mitochondrial function, and neddylation were tied to ApoE4. In serum, these modules predicted AD up to two decades in advance. A clinical trial showed atomoxetine, a norepinephrine reuptake inhibitor, could mitigate some AD-associated pathways, particularly glycolysis.