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BioNTech

BioNTech logo
🇩🇪Germany
Ownership
Public
Employees
6.1K
Market Cap
$20.7B
Website
http://www.biontech.de
Introduction

BioNTech SE operates as immunotherapy company, which engages therapies for cancer and other serious diseases. Its product pipeline include BNT162b2, BNT161, BNT164, FixVac, iNeST, RiboMabs, CAR-T Cells, TCRs and Next-Gen CP Immunomodulators. The company was founded by Christopher Huber, Oezlem Tuereci, and Ugur Sahin on June 2, 2008 and is headquartered in Mainz, Germany.

Clinical Trials

110

Active:48
Completed:24

Trial Phases

5 Phases

Phase 1:70
Phase 2:21
Phase 3:7
+2 more phases

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (105 trials with phase data)• Click on a phase to view related trials

Phase 1
70 (66.7%)
Phase 2
21 (20.0%)
Phase 3
7 (6.7%)
Not Applicable
5 (4.8%)
phase_1_2
1 (1.0%)
Phase 4
1 (1.0%)

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

Not Applicable
Not yet recruiting
Conditions
Metastatic Colorectal Cancer
Interventions
Drug: SoC chemotherapy treatment 1
Drug: SoC chemotherapy treatment 2
First Posted Date
2025-07-23
Last Posted Date
2025-07-23
Lead Sponsor
BioNTech SE
Target Recruit Count
482
Registration Number
NCT07079631

A Study to Learn About COVID-19 RNA-Based Variant-Adapted Vaccine Candidate(s) Against SARS-CoV-2 in Adults, Including Those at Higher Risk of Severe COVID-19

Not Applicable
Not yet recruiting
Conditions
COVID-19
SARS-COV-2 Infection
Interventions
Biological: BNT162b2 (Omi LP.8.1)
First Posted Date
2025-07-16
Last Posted Date
2025-07-16
Lead Sponsor
BioNTech SE
Target Recruit Count
100
Registration Number
NCT07069309
Locations
🇺🇸

Diablo Clinical Research, Inc., Walnut Creek, California, United States

🇺🇸

Indago Research & Health Center, Inc, Hialeah, Florida, United States

🇺🇸

Bio-Kinetic Clinical Applications, LLC dba QPS-MO, Springfield, Missouri, United States

and more 3 locations

A Clinical Study Investigating the Therapeutic Effects and Safety of an Investigational Cell Therapy Given With and Without an Additional Investigational Product in Males With Testicular Cancer or a Form of Cancer That Developed From Sperm

Phase 2
Withdrawn
Conditions
Testicular Germ Cell Tumor
Extragonadal Germ Cell Tumor
Interventions
Biological: CLDN6 CAR-T
First Posted Date
2025-04-23
Last Posted Date
2025-07-02
Lead Sponsor
BioNTech SE
Target Recruit Count
150
Registration Number
NCT06940804

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Phase 1
Recruiting
Conditions
Advanced Lung Cancer
Interventions
First Posted Date
2025-03-24
Last Posted Date
2025-07-11
Lead Sponsor
BioNTech SE
Target Recruit Count
594
Registration Number
NCT06892548
Locations
🇺🇸

Precision NextGen Oncology and Research Center, Beverly Hills, California, United States

🇺🇸

Virginia Cancer Specialists, Fairfax, Virginia, United States

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News

Turkish Study Links Pfizer COVID-19 Vaccine to Corneal Structural Changes

A Turkish study of 64 patients found measurable corneal changes 75 days after receiving two doses of the Pfizer-BioNTech COVID-19 vaccine, including 2% increased thickness and 8% reduced endothelial cell density.

BioNTech Chief Strategy Officer Ryan Richardson to Step Down After Seven-Year Tenure

Ryan Richardson will step down as Chief Strategy Officer from BioNTech's Management Board on September 30, 2025, after serving since January 2020.

Regeneron and BioNTech Advance Phase 2 Trial Combining Cancer Vaccine BNT116 with Cemiplimab for Advanced NSCLC

Regeneron Pharmaceuticals and BioNTech SE are conducting a Phase 2 clinical trial evaluating the combination of investigational cancer vaccine BNT116 with cemiplimab versus cemiplimab monotherapy in advanced non-small cell lung cancer patients with PD-L1 expression ≥50%.

Sartorius Stedim Biotech Partners with Sensible Biotechnologies to Scale Cell-Based mRNA Manufacturing Platform

Sartorius Stedim Biotech and Sensible Biotechnologies have signed a Memorandum of Understanding to advance the industrialization of Sensible's first-in-class cell-based mRNA manufacturing platform.

Everest Medicines Advances AI-Powered mRNA Platform with Cancer Vaccine Breakthroughs

Everest Medicines unveiled major breakthroughs in its proprietary AI-powered mRNA platform during its 2025 R&D Day, showcasing a fully integrated system spanning antigen design to manufacturing.

NCT/UCC Dresden Launches Phase 2 Trial of Personalized mRNA Vaccine for Pancreatic Cancer

NCT/UCC Dresden becomes the only site in Saxony to offer patients access to BioNTech and Genentech's personalized mRNA vaccine Autogene Cevumeran for pancreatic cancer treatment.

BioNTech Shuts Down Maryland Cell Therapy Manufacturing Following CAR-T Trial Failure

BioNTech will lay off 63 employees and wind down cell therapy manufacturing at its Gaithersburg, Maryland facility by the end of 2025 following disappointing Phase 1 trial results.

BioNTech to Acquire CureVac for $1.25 Billion to Strengthen mRNA Cancer Immunotherapy Pipeline

BioNTech announced a $1.25 billion all-stock acquisition of CureVac through a public exchange offer, offering $5.46 per CureVac share representing a 55% premium to strengthen its mRNA-based cancer immunotherapy capabilities.

RFK Jr. Replaces Entire CDC Vaccine Advisory Committee with Eight New Members

Health Secretary Robert F. Kennedy Jr. has replaced all 17 members of the CDC's Advisory Committee on Immunization Practices with eight new appointees, significantly downsizing the committee.

Bristol Myers Squibb Partners with BioNTech in $11.1 Billion Deal for Dual-Target Cancer Immunotherapy

Bristol Myers Squibb will pay BioNTech $1.5 billion upfront plus $2 billion in anniversary payments through 2028 for a 50% partnership in BNT327, a bispecific antibody targeting both PD-L1 and VEGF proteins.

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