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NextCure

NextCure logo
🇺🇸United States
Ownership
Public
Established
2015-01-01
Employees
82
Market Cap
-
Website
http://www.nextcure.com
Introduction

NextCure, Inc. is a clinical-stage biopharmaceutical company, which engages in discovering and developing immunomedicines to treat cancer and other immune-related diseases. Its novel FIND-IO discovery technology identifies targets based on immunomodulatory function and on which the company is building a proprietary pipeline of immunomedicines. The company was founded by Michael S. Richman and Lie Ping Chen in September 2015 and is headquartered in Beltsville, MD.

Clinical Trials

8

Active:1
Completed:1

Trial Phases

1 Phases

Phase 1:8

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (8 trials with phase data)• Click on a phase to view related trials

Phase 1
8 (100.0%)

A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

Phase 1
Recruiting
Conditions
Advanced Solid Tumors
Interventions
Drug: SIM0505 for injection
First Posted Date
2025-01-24
Last Posted Date
2025-08-22
Lead Sponsor
NextCure, Inc.
Target Recruit Count
414
Registration Number
NCT06792552
Locations
🇺🇸

Hackensack University Medical Center, Hackensack, New Jersey, United States

🇨🇳

The first medical center of PLA general hospital, Beijing, Beijing, China

🇨🇳

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

and more 4 locations

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

Phase 1
Recruiting
Conditions
Ovarian Cancer
Endometrial Cancer
Breast Cancer
Biliary Tract Cancer
Non-Small Cell Lung Cancer
Advanced or Metastatic Solid Tumors
Interventions
First Posted Date
2025-01-14
Last Posted Date
2025-05-14
Lead Sponsor
NextCure, Inc.
Target Recruit Count
145
Registration Number
NCT06774963
Locations
🇺🇸

Dana Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

Washington University, Siteman Cancer Center, Saint Louis, Missouri, United States

🇺🇸

Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States

and more 6 locations

A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms

Phase 1
Terminated
Conditions
Relapsed or Refractory Chronic Myelomonocytic Leukemia
Relapsed or Refractory Myelodysplastic Syndrome
Relapsed or Refractory Acute Myeloid Leukemia
Interventions
First Posted Date
2023-03-28
Last Posted Date
2025-04-24
Lead Sponsor
NextCure, Inc.
Target Recruit Count
28
Registration Number
NCT05787496
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

University of Miami, Miami, Florida, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 8 locations

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors

Phase 1
Active, not recruiting
Conditions
Ovarian Cancer
Colo-rectal Cancer
Advanced or Metastatic Solid Tumors
Lung Cancer
Microsatellite Instability High
Microsatellite Stable
Endometrial Cancer
Cervical Cancer
Esophageal Cancer
Microsatellite Instability Low
Interventions
First Posted Date
2022-10-10
Last Posted Date
2024-12-16
Lead Sponsor
NextCure, Inc.
Target Recruit Count
97
Registration Number
NCT05572684
Locations
🇺🇸

Arizona Oncology Associates, Tucson, Arizona, United States

🇺🇸

Rocky Mountain Cancer Centers, Aurora, Colorado, United States

🇺🇸

St. Elizabeth Edgewood Hospital, Edgewood, Kentucky, United States

and more 14 locations

A Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastatic Solid Tumors

Phase 1
Terminated
Conditions
Advanced or Metastatic Solid Tumors
Breast Cancer
Ovarian Cancer
Non-small Cell Lung Cancer
Interventions
First Posted Date
2021-05-06
Last Posted Date
2025-04-22
Lead Sponsor
NextCure, Inc.
Target Recruit Count
40
Registration Number
NCT04875806
Locations
🇺🇸

Yale Cancer Center, New Haven, Connecticut, United States

🇺🇸

The University of Chicago Medicine and Biological Sciences, Chicago, Illinois, United States

🇺🇸

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States

and more 5 locations
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