MedPath

Disc Medicine

🇺🇸United States
Ownership
Public
Employees
74
Market Cap
-
Website
http://www.discmedicine.com
Introduction

Disc Medicine, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of treatments for hematologic diseases. The company was founded in October 2017 and is headquartered in Watertown, MA.

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

Phase 2
Not yet recruiting
Conditions
Polycythemia Vera (PV)
Interventions
First Posted Date
2025-05-22
Last Posted Date
2025-05-22
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
20
Registration Number
NCT06985147

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

Phase 3
Recruiting
Conditions
Erythropoietic Protoporphyria (EPP)
X-Linked Protoporphyria (XLP)
Interventions
Drug: Placebo
First Posted Date
2025-04-04
Last Posted Date
2025-05-13
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
150
Registration Number
NCT06910358
Locations
🇺🇸

Marvel Clinical Research, Huntington Beach, California, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

MetroBoston Clinical Partners, Boston, Massachusetts, United States

and more 1 locations

A Study of DISC-3405 in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteer
Interventions
Drug: Placebo
First Posted Date
2023-09-22
Last Posted Date
2024-12-18
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
64
Registration Number
NCT06050915
Locations
🇺🇸

Celerion, Lincoln, Nebraska, United States

Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants with EPP

Phase 2
Conditions
Erythropoietic Protoporphyria
Interventions
First Posted Date
2023-06-01
Last Posted Date
2024-11-15
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
200
Registration Number
NCT05883748
Locations
🇺🇸

University of Miami Miller School of Medicine, Miami, Florida, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Einstein Medical Center, Philadelphia, Pennsylvania, United States

and more 8 locations

Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants with CKD and Anemia

Phase 1
Recruiting
Conditions
Chronic Kidney Diseases
Anemia of Chronic Kidney Disease
Interventions
Drug: Placebo
First Posted Date
2023-02-27
Last Posted Date
2024-11-15
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
50
Registration Number
NCT05745883
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Rocky Mountain Kidney Care - Lone Tree, Lone Tree, Colorado, United States

🇺🇸

Accel Research, DeLand, Florida, United States

and more 9 locations

Study of DISC-0974 in Participants with Myelofibrosis or Myelodysplastic Syndrome and Anemia

Phase 1
Recruiting
Conditions
Myelofibrosis; Anemia
Myelofibrosis
Myelofibrosis Due to and Following Polycythemia Vera
Primary Myelofibrosis
Anemia
Post-essential Thrombocythemia Myelofibrosis
Myelodysplastic Syndromes
Interventions
First Posted Date
2022-04-11
Last Posted Date
2024-12-12
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
150
Registration Number
NCT05320198
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

🇺🇸

Mayo Clinic Jacksonville, Jacksonville, Florida, United States

🇺🇸

University of Michigan, Ann Arbor, Michigan, United States

and more 12 locations

Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP

Phase 2
Active, not recruiting
Conditions
Erythropoietic Protoporphyria
Interventions
Drug: Placebo
First Posted Date
2022-04-04
Last Posted Date
2024-04-15
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
75
Registration Number
NCT05308472
Locations
🇺🇸

Einstein Medical Center, Philadelphia, Pennsylvania, United States

🇺🇸

University of Texas, Galveston, Texas, United States

🇺🇸

Fred Hutchinson Cancer Center, Seattle, Washington, United States

and more 6 locations

Study to Evaluate the Safety, Tolerability, PK and PD of DISC-0974 in Healthy Subjects

Phase 1
Completed
Conditions
Healthy Volunteer
Interventions
Drug: Placebo
First Posted Date
2021-08-11
Last Posted Date
2022-07-19
Lead Sponsor
Disc Medicine, Inc
Target Recruit Count
42
Registration Number
NCT04999527
Locations
🇺🇸

Worldwide Clinical Trials, San Antonio, Texas, United States

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