National Human Genome Research Institute

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private, Subsidiary

Established: 1989-01-01

Employees: 251

Market Cap: -

Website: https://www.genome.gov

Clinical Trials

Deciphering the Genetic Architecture of Autoimmune Diseases

Recruiting

Conditions: Autoimmune Diseases

First Posted Date: 2025-04-29

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 300

Registration Number: NCT06948110

Locations: 🇺🇸
National Human Genome Research Institute (NHGRI), Bethesda, Maryland, United States
🇵🇪
Amazon Rainforest, Lima, Peru

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

Not yet recruiting

Conditions: Sickle Cell Disease

First Posted Date: 2025-04-25

Last Posted Date: 2025-05-14

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 50

Registration Number: NCT06944067

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Childhood-Onset Essential Hypertension Natural History Study

Recruiting

Conditions: Hypertension
Essential Hypertension

First Posted Date: 2025-01-16

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 2300

Registration Number: NCT06778239

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

Phase 2

Recruiting

Conditions: Focal Segmental Glomerulosclerosis

Interventions: Drug: ManNAc

First Posted Date: 2024-10-30

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 30

Registration Number: NCT06664814

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Genetic Analysis of Uncommon Disease Presentations in Non-US Populations

Recruiting

Conditions: Undiagnosed Diseases
Rare Diseases

First Posted Date: 2024-09-19

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 400

Registration Number: NCT06595940

Locations: 🇲🇺
University of Mauritius, Moka, Mauritius

Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers

Not Applicable

Not yet recruiting

Conditions: Healthy Volunteers
Virtual Reality

Interventions: Behavioral: Motion Reset
Behavioral: Placebo

First Posted Date: 2024-08-14

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 150

Registration Number: NCT06552754

Locations: 🇺🇸
Iowa State University, Ames, Iowa, United States
🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Care Choreographies and the Making of the Psychosocial in Genetic Counseling

Recruiting

Conditions: Genetic Counselor

First Posted Date: 2024-02-28

Last Posted Date: 2025-05-21

Lead Sponsor: National Human Genome Research Institute (NHGRI)

Target Recruit Count: 250

Registration Number: NCT06280833

Locations: 🇺🇸
National Human Genome Research Institute (NHGRI), Bethesda, Maryland, United States

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Recruiting

Conditions: AMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency
TPMT, OMIM *187680, Thoipurines, Poor Metabolism of
HPRT1, OMIM *308000 Lesch-Nyhan Disease
ADSL, OMIM *608222, Adenylosuccinate Lyase Deficiency
PRPS1 SA, OMIM *311850 Gout, PRPS-related Phosphoribosylpyrophosphate Synthetase Superactivity
PNP, OMIM *164050, Nucleoside Phosphorylase Deficiency
CAD, *1140120, Developmental and Epileptic Encephalopathy
Metabolic Disease
ITPA, OMIM *147520, Inosine Triphosphatase Deficiency; Developmental and Epileptic Encephalopathy 35
ADA2, OMIM *607575,Sneddon Syndrome; VAIHS