University of Glasgow

Finerenone reduced CV death and worsening HF risk by 16% in HF patients with mildly reduced or preserved ejection fraction, per FINEARTS-HF trial. Pooled analyses showed benefits of finerenone and MRAs in high-risk patients.

Finerenone reduced heart failure events and cardiovascular death in HF patients with mildly reduced or preserved ejection fraction. The trial, led by Brigham and Women's Hospital and funded by Bayer, showed fewer HF events and cardiovascular deaths in the finerenone group compared to placebo, with higher rates of hyperkalemia. Results were presented at the European Society of Cardiology Congress 2024 and published in the New England Journal of Medicine.

Additional data from SEQUOIA-HCM trial show aficamten improves cardiac remodeling, structure, function, symptoms, and biomarkers in patients with obstructive hypertrophic cardiomyopathy (HCM). Presentations at the European Society of Cardiology Congress 2024 were accompanied by four simultaneous journal publications. Cytokinetics to host a conference call on September 3rd to discuss these findings.