Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)
Not Applicable
Completed
- Conditions
- Tobacco Use
- Interventions
- Other: NP2-4mgOther: NP2-6 mgOther: Loz-4mgOther: Gum-4mg
- First Posted Date
- 2023-12-14
- Last Posted Date
- 2024-08-13
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 56
- Registration Number
- NCT06171490
- Locations
- 🇨🇦
Pharma Medica Research Inc., Toronto, Ontario, Canada
🇨🇦Syneos Health Clinique Inc., Québec, Canada
Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG
Not Applicable
Completed
- Conditions
- Smoking, Tobacco
- Interventions
- Other: P1R stickOther: P1M stickOther: CIG
- First Posted Date
- 2023-03-29
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 31
- Registration Number
- NCT05789420
- Locations
- 🇬🇧
Celerion, Belfast, United Kingdom
Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
Not Applicable
Completed
- Conditions
- SmokingTobacco UseTobacco Smoking
- Interventions
- Other: THS Blade deviceOther: THS Induction Mono deviceOther: THS Induction Mid deviceOther: CIG
- First Posted Date
- 2022-10-31
- Last Posted Date
- 2023-05-26
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 79
- Registration Number
- NCT05599451
- Locations
- 🇬🇧
Celerion, Belfast, United Kingdom
Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.
Not Applicable
Recruiting
- Conditions
- Tobacco UseCOPDSmoking
- Interventions
- Other: CigaretteOther: Smoking AbstinenceOther: THS use
- First Posted Date
- 2022-10-06
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 1895
- Registration Number
- NCT05569005
- Locations
- 🇺🇸
UX12; Solution Clinical Research, Doral, Florida, United States
🇺🇸UX10; Unique Clinical Trials, LLC, Doral, Florida, United States
🇺🇸UX08; TBC Research Corp., Tamarac, Florida, United States
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
Not Applicable
Withdrawn
- Conditions
- SmokingPeripheral Arterial DiseaseCardiovascular DiseasesCoronary Artery DiseaseTobacco Use
- Interventions
- Other: CigaretteOther: THSOther: Smoking Abstinence
- First Posted Date
- 2022-10-04
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Philip Morris Products S.A.
- Registration Number
- NCT05566678
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
Not Applicable
Completed
- Conditions
- NicotineNicotine VapingVaping
- Interventions
- Other: CIGOther: Smoking AbstinenceOther: P4M3 CA35Other: P4M3 CM35
- First Posted Date
- 2022-08-04
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 74
- Registration Number
- NCT05487456
- Locations
- 🇬🇧
Celerion, Belfast, United Kingdom
Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking
Completed
- Conditions
- InflammationSmoking AbstinenceOxidative StressSmoking
- First Posted Date
- 2022-05-23
- Last Posted Date
- 2024-04-30
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 952
- Registration Number
- NCT05385055
Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes
Not Applicable
Completed
- Conditions
- NicotineNicotine VapingVaping
- Interventions
- Other: CA35Other: CM35Other: Cig
- First Posted Date
- 2022-05-20
- Last Posted Date
- 2024-04-26
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 36
- Registration Number
- NCT05383508
- Locations
- 🇺🇸
High Point Clinical Trials Center (HPCTC), High Point, North Carolina, United States
Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouch 1.0 Compared to Velo® Ice Cool and Zyn® Cool Mint Mini Dry in Healthy Smokers
Not Applicable
Completed
- Conditions
- NicotineSmoking
- Interventions
- Other: NP-1Other: NP-2Other: NP-3Other: NP-4Other: Velo-NPOther: Zyn-NP
- First Posted Date
- 2022-04-07
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 24
- Registration Number
- NCT05317195
- Locations
- 🇬🇧
Celerion, Belfast, Northern Ireland, United Kingdom
Product Use and Adaptation, Safety and Tolerability of P3P in Adult Healthy Smokers Switching to it
Not Applicable
Completed
- Conditions
- Pharmacokinetics
- Interventions
- Other: P3P-1mgOther: P3P-2mg
- First Posted Date
- 2019-05-16
- Last Posted Date
- 2020-12-14
- Lead Sponsor
- Philip Morris Products S.A.
- Target Recruit Count
- 60
- Registration Number
- NCT03953183
- Locations
- 🇷🇺
LLC Scientific Research Center Eco-Safety, St. Petersburg, Russian Federation
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