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Roche Holding AG

Roche Holding AG logo
🇨🇭Switzerland
Ownership
Public
Established
1896-01-15
Employees
103.6K
Market Cap
$270.5B
Website
http://www.roche.com

A Study of the Efficacy and Safety of Bevacizumab in Chinese Women With Newly Diagnosed, Previously Untreated Stage III or Stage IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 3
Completed
Conditions
Ovarian Cancer
Fallopian Tube Cancer
Primary Peritoneal Cancer
Interventions
First Posted Date
2018-08-17
Last Posted Date
2024-10-03
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
100
Registration Number
NCT03635489
Locations
🇨🇳

the First Hospital of Jilin University, Changchun, China

🇨🇳

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing City, China

🇨🇳

Tianjin Medical University General Hospital, Tianjin, China

and more 13 locations

Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms

Phase 3
Completed
Conditions
Influenza
Interventions
First Posted Date
2018-08-14
Last Posted Date
2020-04-29
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
173
Registration Number
NCT03629184
Locations
🇺🇸

The Probe Medical Research, Los Angeles, California, United States

🇺🇸

Kentucky Pediatric Research Center, Bardstown, Kentucky, United States

🇺🇸

Orange County Research Institute, Ontario, California, United States

and more 34 locations

A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases

Phase 2
Completed
Conditions
Metastatic Melanoma
Interventions
First Posted Date
2018-08-10
Last Posted Date
2024-04-11
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
80
Registration Number
NCT03625141
Locations
🇧🇷

Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro, RJ, Brazil

🇧🇷

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, RS, Brazil

🇧🇷

Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil

and more 19 locations

A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE)

Phase 3
Completed
Conditions
Diabetic Macular Edema
Interventions
Drug: Faricimab
Drug: Aflibercept
Procedure: Sham Procedure
First Posted Date
2018-08-09
Last Posted Date
2022-09-16
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
940
Registration Number
NCT03622580
Locations
🇺🇸

Orange County Retina Med Group, Santa Ana, California, United States

🇺🇸

Kaiser Permanente Riverside Medical Center, Riverside, California, United States

🇺🇸

Cumberland Valley Retina PC, Hagerstown, Maryland, United States

and more 181 locations

A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema

Phase 3
Completed
Conditions
Diabetic Macular Edema
Interventions
Drug: Aflibercept
Drug: Faricimab
Procedure: Sham Procedure
First Posted Date
2018-08-09
Last Posted Date
2024-06-04
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
951
Registration Number
NCT03622593
Locations
🇨🇦

Toronto Retina Institute, Toronto, Ontario, Canada

🇨🇦

Unity Health Toronto, Toronto, Ontario, Canada

🇺🇸

Retina Consultants of Nevada, Las Vegas, Nevada, United States

and more 191 locations

A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD)

Phase 1
Completed
Conditions
Autism Spectrum Disorder
Interventions
Other: No Intervention
First Posted Date
2018-08-02
Last Posted Date
2022-06-21
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
144
Registration Number
NCT03611075
Locations
🇺🇸

PCSD Feighner Research, San Diego, California, United States

🇺🇸

Southwest Autism Research and Resource Center, Phoenix, Arizona, United States

🇺🇸

Harmonex Neuroscience Research, Dothan, Alabama, United States

and more 15 locations

This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS)

Phase 3
Active, not recruiting
Conditions
Multiple Sclerosis
Interventions
First Posted Date
2018-07-26
Last Posted Date
2024-11-07
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
1500
Registration Number
NCT03599245
Locations
🇦🇷

Centro de Especialidades Neurológicas y Rehabilitación - CENyR, Buenos Aires, Argentina

🇧🇷

Instituto de Neurologia de Curitiba, Curitiba, PR, Brazil

🇧🇪

UZ Antwerpen, Edegem, Belgium

and more 159 locations

Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Participants
Interventions
First Posted Date
2018-07-24
Last Posted Date
2018-12-06
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
8
Registration Number
NCT03596632
Locations
🇺🇸

Covance Clinical Research Unit, Inc, Madison, Wisconsin, United States

Non-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Sclerosis

Active, not recruiting
Conditions
Multiple Sclerosis
Interventions
First Posted Date
2018-07-20
Last Posted Date
2024-12-05
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
1710
Registration Number
NCT03593590
Locations
🇧🇪

Revalidatie en MS Centrum, Overpelt, Belgium

🇧🇬

Multiprofile Hosp. for Active Treatment;National Cardiology Hosp., Sofia, Bulgaria

🇧🇬

"City Clinic UMHAC" EOOD, Sofia, Bulgaria

and more 161 locations

A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting

Phase 4
Completed
Conditions
Multiple Sclerosis
Interventions
Drug: Ocrelizumab 300 mg
Drug: Ocrelizumab 600 mg
First Posted Date
2018-07-17
Last Posted Date
2022-01-11
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
423
Registration Number
NCT03589105
Locations
🇫🇷

CHU de la Timone - Hopital d Adultes; Service de Neurologie, Marseille, France

🇫🇷

Fondation Hopital Saint Joseph; Neurologie, Marseille, France

🇫🇷

Centre hospitalier Annecy Genevois Site St Julien; Neurologie, Metz Tessy, France

and more 43 locations
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