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Roche Holding AG

Roche Holding AG logo
🇨🇭Switzerland
Ownership
Public
Established
1896-01-15
Employees
103.6K
Market Cap
$270.5B
Website
http://www.roche.com

A Study Comparing the Efficacy and Safety of Etrolizumab to Infliximab in Participants With Moderate to Severe Ulcerative Colitis Who Are Naïve to Tumor Necrosis Factor (TNF) Inhibitors

Phase 3
Completed
Conditions
Ulcerative Colitis
Interventions
Drug: Etrolizumab
Drug: Infliximab
Other: Placebo (IV)
Other: Placebo (Injection)
First Posted Date
2014-05-12
Last Posted Date
2021-12-03
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
397
Registration Number
NCT02136069
Locations
🇮🇱

Chaim Sheba Medical Center; Pediatrics B North and Pediatric Endocrinology Unit, Tel Hashomer, Israel

🇭🇺

Eszak-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo, Budapest, Hungary

🇭🇺

Vasutegeszsegugyi Nonprofit KiemeltenKozhasznu Kft, Debrecen, Hungary

and more 116 locations

A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteer
Interventions
First Posted Date
2014-05-08
Last Posted Date
2016-11-02
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
31
Registration Number
NCT02133937

A Study Examining Long Response in Lung Cancer Patients Treated With Tarceva (Erlotinib)

Completed
Conditions
Non-Small Cell Lung Cancer
First Posted Date
2014-05-08
Last Posted Date
2017-10-24
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
172
Registration Number
NCT02133508
Locations
🇮🇹

A.O. Universitaria Policlinico Di Modena; Ematologia, Modena, Emilia-Romagna, Italy

🇮🇹

Ospedale Provinciale Santa Maria delle Croci, Ravenna, Emilia-Romagna, Italy

🇮🇹

Azienda Ospedaliera San Giuseppe Moscati, Avellino, Campania, Italy

and more 36 locations

A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer

First Posted Date
2014-05-07
Last Posted Date
2021-09-17
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
401
Registration Number
NCT02132949
Locations
🇵🇱

Wielkopolskie Centrum Onkologii; im. Marii Skłodowskiej-Curie, Poznan, Poland

🇵🇹

Centro Clinico Champalimaud; Oncologia Medica, Lisboa, Portugal

🇺🇸

Berkshire Medical Center, Pittsfield, Massachusetts, United States

and more 77 locations

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

First Posted Date
2014-05-06
Last Posted Date
2019-07-02
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
444
Registration Number
NCT02131064
Locations
🇺🇸

Cancer Care Assoc Med Group, Los Angeles, California, United States

🇺🇸

New England Cancer Specialists, Scarborough, Maine, United States

🇺🇸

Hope A Women's Cancer Center, Asheville, North Carolina, United States

and more 76 locations

Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies

Phase 3
Terminated
Conditions
Ulcerative Colitis
Interventions
First Posted Date
2014-04-21
Last Posted Date
2024-10-23
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
1822
Registration Number
NCT02118584
Locations
🇩🇰

Rigshospitalet; Afdeling for Tarmsvigt og Leversygdomme, København Ø, Denmark

🇭🇺

Semmelweis Egyetem; Belgyogyaszati es Hematologiai Klinika, Budapest, Hungary

🇺🇸

University of Alabama Medical Center, Birmingham, Alabama, United States

and more 408 locations

An Observational Study Examining the Use of Triple Combination Therapy With Boceprevir, Peginterferon Alfa-2a and Ribavirin in the Re-Treatment of Chronic Hepatitis C Patients

Terminated
Conditions
Hepatitis C, Chronic
Interventions
Drug: Boceprevir
Drug: Simeprevir
Drug: Pegylated Interferon (Peginterferon) Alfa-2a
Drug: Ribavirin
First Posted Date
2014-04-21
Last Posted Date
2016-12-12
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
19
Registration Number
NCT02118597

A Study Evaluating the Safety and Efficacy of Rituximab in Combination With Glucocorticoids in Participants With Wegener's Granulomatosis or Microscopic Polyangitis

Phase 4
Completed
Conditions
Wegener's Granulomatosis or Microscopic Polyangiitis
Interventions
First Posted Date
2014-04-16
Last Posted Date
2022-07-06
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
30
Registration Number
NCT02115997
Locations
🇮🇳

Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute; Department of Rheumatologz, Mumbai, Maharashtra, India

🇮🇳

St. John's Medical College Hospital; Rheumatology, Bangalore, India

🇮🇳

Medanta-The Medicity, Gurgaon, Haryana, India

and more 7 locations

A Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer (Cohort 2)

Phase 2
Completed
Conditions
Bladder Cancer
Interventions
First Posted Date
2014-04-09
Last Posted Date
2024-03-28
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
310
Registration Number
NCT02108652
Locations
🇺🇸

Mayo Clinic Cancer Center, Jacksonville, Florida, United States

🇺🇸

Stanford Cancer Center, Stanford, California, United States

🇺🇸

Willamette Valley Cancer Ctr - 520 Country Club, Eugene, Oregon, United States

and more 74 locations
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