JICHI MEDICAL UNIVERSITY

Researchers from Institute of Science Tokyo discovered that tongue cancer cells resist chemotherapy by activating autophagy and cholesterol synthesis pathways. Using a library of tongue cancer organoids, they identified mechanisms behind minimal residual disease, offering new treatment avenues. Their findings, published in Developmental Cell, highlight potential for personalized medicine in combating chemo-resistant tongue cancer.

Researchers from Leiden University Medical Center and Radboud University engineered mosquitoes to deliver vaccines, potentially enhancing immunity against malaria. The vaccine uses a weakened Plasmodium falciparum parasite, which does not cause disease symptoms. Trials showed 13% and 89% immunity in GA1 and GA2 groups, respectively. Further research is needed for larger-scale testing and protection against different malaria strains.