University Health Network

🇨🇦Canada

Country: 🇨🇦Canada

Ownership: Private

Established: 1999-01-01

Employees: 10K

Market Cap: -

Website: http://www.uhn.ca

Clinical Trials

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Not Applicable

Recruiting

Conditions: Respiratory Insufficiency
Extracorporeal Membrane Oxygenation Complication
Mechanical Ventilation Pressure High

Interventions: Other: Ultra-Protective Ventilation Facilitated by Extracorporeal Support
Drug: Early Cohort corticosteroid dose
Drug: 4 mL of nebulized 0.9% saline minutes every 6 hours over 30 minutes every 6 hours.
Other: PEEP-20
Drug: Usual care with fludrocortisone
Other: Lung-Protective Ventilation (LPV)
Other: Driving Pressure-Limited Ventilation (DPL)
Drug: Extended Cohort corticosteroid dose
Drug: 40 mg of nebulized furosemide in 4 mL of saline nebulized over 30 minutes every 6 hours
Other: PEEP-AOP
Drug: Usual care without fludrocortisone
Other: Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)
Drug: Usual care without routine corticosteroids
Other: PEEP-10
Drug: Usual care without extending corticosteroids

First Posted Date: 2022-07-01

Last Posted Date: 2025-02-11

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 6250

Registration Number: NCT05440851

Locations: 🇨🇦
University Health Network, Toronto, Canada

Characterization of Bleeding Disorders in EDS

Conditions: Classical EDS (cEDS)
Ehlers-Danlos Syndrome
EDS
Classical Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos Syndrome
Vascular Ehlers-Danlos Syndrome
Hypermobile EDS (hEDS)
Vascular EDS (vEDS)

Interventions: Other: 20 ml venous blood collection

First Posted Date: 2022-06-28

Last Posted Date: 2023-05-09

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 45

Registration Number: NCT05434728

Locations: 🇨🇦
GoodHope EDS - Toronto General Hospital, Toronto, Ontario, Canada

PRehab tO PreparE Living Liver Donors for Enhanced Recovery

Not Applicable

Active, not recruiting

Conditions: Living Donor Liver Transplantation

Interventions: Other: Prehabilitation

First Posted Date: 2022-06-24

Last Posted Date: 2024-12-16

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 30

Registration Number: NCT05431361

Locations: 🇨🇦
University Health Network, Toronto, Ontario, Canada

Ultrastructural Collagen Markers in Ehlers Danlos Syndromes

Conditions: Hypermobile EDS (hEDS)
Ehlers-Danlos Syndrome
Classical Ehlers-Danlos Syndrome

Interventions: Other: Skin Biopsy

First Posted Date: 2022-06-24

Last Posted Date: 2023-11-28

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 20

Registration Number: NCT05429996

Locations: 🇨🇦
GoodHope EDS - Toronto General Hospital, Toronto, Ontario, Canada

Rehabilitation for People With Advanced Cancer

Not Applicable

Recruiting

Conditions: Advanced Colorectal Cancer
Cancer Rehabilitation
Advanced Breast Cancer

Interventions: Behavioral: Virtual rehabilitation group
Behavioral: In-person rehabilitaiton group

First Posted Date: 2022-06-21

Last Posted Date: 2024-10-10

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 117

Registration Number: NCT05424068

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Intravenous Vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients

Phase 4

Recruiting

Conditions: Surgery
Hip-fracture

Interventions: Drug: Intravenous (IV) placebo plus oral acetaminophen
Drug: Intravenous (IV) acetaminophen + oral placebo

First Posted Date: 2022-06-21

Last Posted Date: 2025-03-28

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 42

Registration Number: NCT05425355

Locations: 🇨🇦
Toronto Western Hospital (UHN), Toronto, Ontario, Canada

Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC

Phase 2

Recruiting

Conditions: Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)

Interventions: Biological: AZD2936

First Posted Date: 2022-06-10

Last Posted Date: 2025-03-30

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 200

Registration Number: NCT05414032

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Canada

Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)

Phase 2

Recruiting

Conditions: Metastatic Prostate Cancer

Interventions: Other: Standard of Care SBRT and ADT
Drug: Enzalutamide

First Posted Date: 2022-06-03

Last Posted Date: 2024-11-25

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 132

Registration Number: NCT05404139

Locations: 🇨🇦
Princess Margaret Cancer Center, Toronto, Ontario, Canada
🇨🇦
Sunnybrook Research Institute, Toronto, Ontartio, Canada

Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)

Recruiting

Conditions: Kidney Cancer
Pancreas Cancer
Leukemia
Solid Tumor
Colorectal Cancer
Breast Cancer
Head and Neck Cancer
Lung Cancer
Prostate Cancer
Melanoma

First Posted Date: 2022-06-03

Last Posted Date: 2025-02-03

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 500

Registration Number: NCT05403177

Locations: 🇨🇦
Kingston Health Sciences Centre, Kingston, Ontario, Canada
🇨🇦
Ottawa Health Research Institute, Ottawa, Ontario, Canada
🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Biofeedback for Hemianopia Vision Rehabilitation

Not Applicable

Recruiting

Conditions: Brain Injury
Brain Tumor
Stroke
Hemianopsia, Homonymous
Brain Trauma

Interventions: Device: Biofeedback training

First Posted Date: 2022-05-31

Last Posted Date: 2025-05-09

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 32

Registration Number: NCT05397873

Locations: 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada

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