University Health Network

🇨🇦Canada

Country: 🇨🇦Canada

Ownership: Private

Established: 1999-01-01

Employees: 10K

Market Cap: -

Website: http://www.uhn.ca

Clinical Trials

Fluorescence Image-Guided Healing Trial

Phase 4

Conditions: Diabetic Foot Ulcer

First Posted Date: 2019-11-14

Last Posted Date: 2020-11-03

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 294

Registration Number: NCT04163055

A Study of Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Phase 2

Recruiting

Conditions: Endometrial Carcinoma
P53 Mutation
Serous Carcinoma

Interventions: Radiation: External Beam Radiation
Radiation: Vaginal high-dose rate brachytherapy
Other: Observation - no drugs
Drug: Niraparib

First Posted Date: 2019-11-12

Last Posted Date: 2024-01-31

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 267

Registration Number: NCT04159155

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy

Not Applicable

Suspended

Conditions: Surgery
BRCA1 Mutation
Breast Cancer
Surgery--Complications
Breast Diseases
Genetic Predisposition to Disease
BRCA2 Mutation

Interventions: Procedure: Robotic Nipple-Sparing Mastectomy (RNSM)

First Posted Date: 2019-11-05

Last Posted Date: 2023-12-19

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 30

Registration Number: NCT04151368

Locations: 🇨🇦
University Health Network, Toronto, Ontario, Canada

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

Recruiting

Conditions: Malignancies Multiple
Receptor Tyrosine Kinase Gene Mutation
Ras (Kras or Nras) Gene Mutation
Cancer
Molecular Sequence Variation
Cancer, Therapy-Related
Genetic Alteration
Malignant Solid Tumor
Gene Fusion
RTK Family Gene Mutation

Interventions: Drug: Cancer treatment with tyrosine kinase inhibitors (TKIs) or other molecularly targeted therapeutic agents.
Other: Patient-reported outcomes (PROs)

First Posted Date: 2019-11-05

Last Posted Date: 2024-05-31

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 1000

Registration Number: NCT04151342

Locations: 🇨🇦
William Osler Health System - Brampton Civic Hospital, Brampton, Ontario, Canada
🇨🇦
Lawson Health Research Institute - London Health Sciences Centre, London, Ontario, Canada
🇨🇦
CancerCare Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada

and more 24 locations

Breathomics as Predictive Biomarker for Checkpoint Inhibitor Response

Recruiting

Conditions: Melanoma
Urothelial Carcinoma
Head and Neck Cancer
NSCLC
Kidney Cancer

Interventions: Other: Breathprint analysis and patient-reported outcomes

First Posted Date: 2019-10-31

Last Posted Date: 2023-06-05

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 425

Registration Number: NCT04146064

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Magnetic Resonance-Guided Adaptive Radiotherapy (MRgART) Using an Integrated Magnetic Resonance Linear Accelerator (MRL)

Recruiting

Conditions: Cancer

First Posted Date: 2019-10-23

Last Posted Date: 2024-06-18

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 500

Registration Number: NCT04135794

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Dosing Intervals of Opioid Medication for Chronic Pain

Phase 4

Withdrawn

Conditions: Chronic Pain

Interventions: Drug: Extended Release Opioid Formulation, Shortened Intervals
Drug: Extended Release Opioid Formulation, Standard intervals
Drug: Placebo oral tablet

First Posted Date: 2019-10-18

Last Posted Date: 2020-03-27

Lead Sponsor: University Health Network, Toronto

Registration Number: NCT04132011

Locations: 🇨🇦
University Health Network, Toronto, Ontario, Canada

The Role of Stereo-tActic BoDy RadIotherApy iN Oligo-Progressive MalignanT Disease

Not Applicable

Recruiting

Conditions: Malignancy
Breast Cancer Metastatic
Genito-urinary

Interventions: Radiation: Stereotactic Body Radiotherapy

First Posted Date: 2019-10-10

Last Posted Date: 2024-04-11

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 130

Registration Number: NCT04122469

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Factor Replacement in Surgery

Phase 2

Conditions: Bleeding in Cardiac Surgery

Interventions: Biological: Prothrombin Complex Concentrate
Biological: Frozen Plasma

First Posted Date: 2019-10-03

Last Posted Date: 2020-11-03

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 103

Registration Number: NCT04114643

Locations: 🇨🇦
Sunnybrook Health Science Centre, Toronto, Ontario, Canada

Physiological Flow of Liquids in Healthy Swallowing

Completed

Conditions: Healthy Swallowing
Aging
Deglutition

Interventions: Other: Starch-thickened liquids
Other: Xanthan-gum thickened liquids
Combination Product: Barium concentration

First Posted Date: 2019-10-03

Last Posted Date: 2022-12-21

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 80

Registration Number: NCT04114617

Locations: 🇨🇦
Toronto Rehabilitation Institute, Toronto, Ontario, Canada

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