University Health Network

🇨🇦Canada

Country: 🇨🇦Canada

Ownership: Private

Established: 1999-01-01

Employees: 10K

Market Cap: -

Website: http://www.uhn.ca

Clinical Trials

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors

Phase 2

Active, not recruiting

Conditions: Mismatch Repair Proficient Colorectal Cancer
Pancreatic Adenocarcinoma
Leiomyosarcoma

Interventions: Biological: Durvalumab
Drug: Olaparib
Drug: Cediranib

First Posted Date: 2019-02-22

Last Posted Date: 2024-03-15

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 90

Registration Number: NCT03851614

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

The Impact of Fluid Volume Shifts on Upper Airway Collapse and Obstructive Sleep Apnea in Surgical Patients

Terminated

Conditions: Obstructive Sleep Apnea

First Posted Date: 2019-02-21

Last Posted Date: 2022-06-23

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 50

Registration Number: NCT03850041

Locations: 🇨🇦
Toronto General Hospital, Toronto, Ontario, Canada
🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada

Self-Management and Activation to Reduce Treatment-Related Toxicities (SMARTCare)

Not Applicable

Terminated

Conditions: Lung Cancer
Colo-rectal Cancer
Lymphoma

Interventions: Other: Control
Other: SMARTCare

First Posted Date: 2019-02-21

Last Posted Date: 2021-09-30

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 62

Registration Number: NCT03849950

Locations: 🇨🇦
Royal Victoria Regional Health Centre, Barrie, Ontario, Canada
🇨🇦
Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations

Phase 2

Active, not recruiting

Conditions: Solid Tumor

Interventions: Drug: Binimetinib
Drug: Encorafenib

First Posted Date: 2019-02-15

Last Posted Date: 2024-05-08

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 26

Registration Number: NCT03839342

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Relationship Between 18FDG PET/MRI Patterns and ctDNA to Predict HCC Recurrence After Liver Transplantation

Not Applicable

Active, not recruiting

Conditions: Hepatocellular Carcinoma

Interventions: Device: PET MRI

First Posted Date: 2019-02-15

Last Posted Date: 2023-12-06

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 20

Registration Number: NCT03839706

Locations: 🇨🇦
Toronto General Hospital, Toronto, Ontario, Canada

Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2

Not Applicable

Active, not recruiting

Conditions: Head and Neck Squamous Cell Carcinoma

Interventions: Drug: MET-4

First Posted Date: 2019-02-12

Last Posted Date: 2024-03-15

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 30

Registration Number: NCT03838601

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

High Resolution Ultrasound in Pancreatic Ductal Adenocarcinoma

Not Applicable

Active, not recruiting

Conditions: Pancreatic Ductal Adenocarcinoma

Interventions: Device: Ultrasound

First Posted Date: 2019-01-29

Last Posted Date: 2024-10-10

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 30

Registration Number: NCT03820661

Locations: 🇨🇦
University Health Network, Toronto, Ontario, Canada

Circulating Tumor DNA in Soft Tissue Sarcoma

Not Applicable

Recruiting

Conditions: Soft Tissue Sarcoma

Interventions: Procedure: Archival tumor tissue collection and blood draws

First Posted Date: 2019-01-28

Last Posted Date: 2024-03-22

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 40

Registration Number: NCT03818412

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

18F-DCFPyL PET/CT in High-grade Epithelial Ovarian Cancer (PET HOC)

Not Applicable

Completed

Conditions: Stage III Ovarian Cancer
Stage IV Ovarian Cancer

Interventions: Diagnostic Test: 18F-DCFPyL

First Posted Date: 2019-01-22

Last Posted Date: 2022-11-02

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 20

Registration Number: NCT03811899

Locations: 🇨🇦
Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Azoles Targeting Recurrent High Grade Gliomas

Early Phase 1

Not yet recruiting

Conditions: Brain Tumor, Recurrent
Cancer, Advanced
Glioma of Brain

Interventions: Drug: Ketoconazole (KCZ)
Drug: Posaconazole (PCZ)

First Posted Date: 2018-12-04

Last Posted Date: 2024-03-08

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 30

Registration Number: NCT03763396

Locations: 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada

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