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Oric Pharmaceuticals

Oric Pharmaceuticals logo
🇺🇸United States
Ownership
Public
Established
2014-01-01
Employees
100
Market Cap
$704.7M
Website
http://www.oricpharma.com
Introduction

Oric Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company, which engages in the development of cancer treatments that address mechanisms of therapeutic resistance. It specializes in hormone-dependent cancers, key tumor dependencies, and precision oncology. The company was founded by Charles L. Sawyers, Richard A. Heyman, and Scott Lowe in 2014 and is headquartered in South San Francisco, CA.

Clinical Trials

9

Active:0
Completed:4

Trial Phases

1 Phases

Phase 1:8

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (9 trials with phase data)• Click on a phase to view related trials

Phase 1
8 (88.9%)
phase_1_2
1 (11.1%)

ORIC-114 in Combination with Subcutaneous Amivantamab in Patients with EGFR Exon20 Insertion Mutant NSCLC

Phase 1
Recruiting
Conditions
EGFR Exon 20 Insertion Mutations
NSCLC
Solid Tumors
EGFR-mutated NSCLC
Interventions
Drug: ORIC-114 Dose 1 + amivantamab
Drug: ORIC-114 Dose 2 + amivantamab
Drug: ORIC-114 Dose 3 + amivantamab
First Posted Date
2025-02-10
Last Posted Date
2025-03-20
Lead Sponsor
ORIC Pharmaceuticals
Target Recruit Count
76
Registration Number
NCT06816992
Locations
🇺🇸

NYU Langone Health, New York, New York, United States

🇺🇸

Virginia Cancer Specialists, Fairfax, Virginia, United States

🇦🇺

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

and more 1 locations

Effect of Food on the Pharmacokinetics of ORIC-114

Phase 1
Completed
Conditions
Food Effect in Healthy Participants
Interventions
First Posted Date
2023-08-25
Last Posted Date
2024-01-19
Lead Sponsor
ORIC Pharmaceuticals
Target Recruit Count
32
Registration Number
NCT06012721
Locations
🇦🇺

Nucleus Network Pty Ltd., 235 Ryrie St, Geelong, Victoria, Australia

🇦🇺

Nucleus Network Pty Ltd., Level 5, Burnet Tower, 89 Commercial Rd, Melbourne, Victoria, Australia

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

First Posted Date
2022-06-10
Last Posted Date
2025-08-11
Lead Sponsor
ORIC Pharmaceuticals
Target Recruit Count
42
Registration Number
NCT05413421
Locations
🇺🇸

Rocky Mountain Cancer Center, Colorado Springs, Colorado, United States

🇺🇸

Illinois Cancer Specialists, Arlington Heights, Illinois, United States

🇺🇸

Comprehensive Urologic Care, Lake Barrington, Illinois, United States

and more 23 locations

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

Phase 1/2
Recruiting
Conditions
Solid Tumors
First Posted Date
2022-04-07
Last Posted Date
2025-08-05
Lead Sponsor
ORIC Pharmaceuticals Inc.
Target Recruit Count
30
Registration Number
2024-512264-66-00
Locations
🇺🇸

City of Hope, Long Beach, California, United States

🇺🇸

University of California, San Francisco, San Francisco, California, United States

🇺🇸

Yale Cancer Center, New Haven, Connecticut, United States

and more 35 locations

Study of ORIC-533 in Relapsed or Refractory Multiple Myeloma

Phase 1
Completed
Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
First Posted Date
2022-02-07
Last Posted Date
2025-03-20
Lead Sponsor
ORIC Pharmaceuticals
Target Recruit Count
31
Registration Number
NCT05227144
Locations
🇺🇸

James R. Berenson, MD, Inc., West Hollywood, California, United States

🇺🇸

Northside Hospital Cancer Institute, Atlanta, Georgia, United States

🇺🇸

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 5 locations
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News

ORIC Pharmaceuticals Appoints Kevin Brodbeck as Chief Technical Officer Ahead of Phase 3 Trials

ORIC Pharmaceuticals has appointed Kevin Brodbeck, PhD, as Chief Technical Officer to support the company's transition into late-stage clinical development.

Biotech Industry Faces Wave of Strategic Layoffs as Companies Prioritize Efficiency and Pipeline Focus

Major pharmaceutical and biotech companies including Pfizer, Johnson & Johnson, Fate Therapeutics, and Generation Bio are implementing workforce reductions as part of industry-wide financial restructuring efforts.

ORIC Pharmaceuticals Announces Promising Early Data for ORIC-944 and Collaboration for ORIC-114

ORIC Pharmaceuticals reported encouraging early data from a Phase 1b trial of ORIC-944 combined with apalutamide in metastatic castration-resistant prostate cancer (mCRPC).

Unicycive and ORIC Pharmaceuticals Receive Buy Ratings Based on Promising Clinical Data

Unicycive Therapeutics' OLC shows promise in treating hyperphosphatemia by reducing pill burden and adverse events, potentially gaining FDA approval by June 2025.

ORIC Pharmaceuticals Presents Promising Data on Cancer Drug Candidates at AACR Meeting

ORIC Pharmaceuticals presented preclinical data on ORIC-944, a PRC2 inhibitor, showing potential as a best-in-class treatment for prostate cancer in combination with AR inhibitors.

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