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Verastem

Verastem logo
🇺🇸United States
Ownership
Public
Established
2010-01-01
Employees
73
Market Cap
-
Website
http://www.verastem.com
Introduction

Verastem, Inc. is a biopharmaceutical company, which engages in the development and commercialization of drugs for the treatment of cancer. The company was founded by Richard H. Aldrich, Michelle Dipp, Piyush Gupta, Satish Jindal, Eric S. Lander, Robert F. Weinberg, and Christoph H. Westphal on August 4, 2010 and is headquartered in Needham, MA.

Clinical Trials

60

Active:35
Completed:8

Trial Phases

3 Phases

Phase 1:48
Phase 2:6
Phase 3:1

Drug Approvals

2

FDA:2

Drug Approvals

AVMAPKI FAKZYNJA CO-PACK

Approval Date
May 1, 2025
FDA

Copiktra

Approval Date
Feb 11, 2022
FDA

Clinical Trials

Distribution across different clinical trial phases (56 trials with phase data)• Click on a phase to view related trials

Phase 1
48 (85.7%)
Phase 2
6 (10.7%)
phase_1_2
1 (1.8%)
Phase 3
1 (1.8%)

A Phase 1/2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Phase 1
Recruiting
Conditions
Pancreatic Ductal Adenocarcinoma
Non Small Cell Lung Cancer
Colorectal Cancer
Solid Tumor, Adult
G12D Mutated KRAS
Interventions
First Posted Date
2025-06-13
Last Posted Date
2025-07-18
Lead Sponsor
Verastem, Inc.
Target Recruit Count
130
Registration Number
NCT07020221
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

🇺🇸

SCRI Oncology Partners, Nashville, Tennessee, United States

and more 2 locations

A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients

Phase 2
Recruiting
Conditions
Low Grade Serous Ovarian Cancer
Ovarian Cancer
Interventions
First Posted Date
2024-11-12
Last Posted Date
2025-02-17
Lead Sponsor
Verastem, Inc.
Target Recruit Count
15
Registration Number
NCT06682572
Locations
🇯🇵

Aichi Cancer Center Hospital, Nagoya, Aichi, Japan

🇯🇵

Kurume University Hospital, Kurume, Fukuoka, Japan

🇯🇵

Mie University Hospital, Tsu, Mie, Japan

and more 2 locations

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

First Posted Date
2023-10-10
Last Posted Date
2025-07-02
Lead Sponsor
Verastem, Inc.
Target Recruit Count
270
Registration Number
NCT06072781
Locations
🇺🇸

HonorHealth, Phoenix, Arizona, United States

🇺🇸

University of Arkansas, Little Rock, Arkansas, United States

🇺🇸

UCLA Health, Los Angeles, California, United States

and more 94 locations

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

Phase 1
Recruiting
Conditions
Metastatic Cancer
Pancreas Cancer
Neoplasms Pancreatic
Malignant Neoplasm of Pancreas
KRAS Activating Mutation
Interventions
First Posted Date
2022-12-30
Last Posted Date
2025-06-24
Lead Sponsor
Verastem, Inc.
Target Recruit Count
40
Registration Number
NCT05669482
Locations
🇺🇸

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States

🇺🇸

University of Chicago, Chicago, Illinois, United States

🇺🇸

Dana Farber Cancer Institute, Boston, Massachusetts, United States

and more 9 locations

Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients

Phase 1
Active, not recruiting
Conditions
Non Small Cell Lung Cancer
KRAS Activating Mutation
Advanced Cancer
Metastatic Cancer
Malignant Neoplastic Disease
Malignant Neoplasm of Lung
Interventions
First Posted Date
2022-05-17
Last Posted Date
2025-05-18
Lead Sponsor
Verastem, Inc.
Target Recruit Count
85
Registration Number
NCT05375994
Locations
🇺🇸

UCSF Thoracic Oncology, San Francisco, California, United States

🇺🇸

University of Colorado Hospital Anschutz Cancer Pavllion, Aurora, Colorado, United States

🇺🇸

Mayo Clinic Cancer Center, Rochester, Minnesota, United States

and more 4 locations
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