JOHN HOPE FRANKLIN CENTER

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private

Established: 1838-01-01

Employees: 5K

Market Cap: -

Website: http://www.duke.edu

Clinical Trials

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

Phase 3

Terminated

Conditions: Mitral Valve Insufficiency
Heart Failure

Interventions: Procedure: Surgical mitral valvuloplasty with placement of annular ring (SMVR)
Drug: Optimal medical therapy (OMT)

First Posted Date: 2008-02-06

Last Posted Date: 2018-04-04

Lead Sponsor: Duke University

Target Recruit Count: 2

Registration Number: NCT00608140

Locations: 🇺🇸
Morehouse School of Medicine, Atlanta, Georgia, United States
🇺🇸
Minnesota Heart Failure Network, Minneapolis, Minnesota, United States
🇺🇸
Baylor College of Medicine, Houston, Texas, United States

and more 6 locations

Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)

Phase 3

Completed

Conditions: Heart Failure

Interventions: Drug: Stepped pharmacologic care
Device: Ultrafiltration

First Posted Date: 2008-02-06

Last Posted Date: 2013-06-24

Lead Sponsor: Duke University

Target Recruit Count: 188

Registration Number: NCT00608491

Locations: 🇺🇸
Mayo Clinic Arizona, Phoenix, Arizona, United States
🇺🇸
University of Utah Health Sciences Center, Murray, Utah, United States
🇺🇸
University of Vermont - Fletcher Allen Health Care, Burlington, Vermont, United States

and more 6 locations

An Open Label, Double-blind Discontinuation Study of Quetiapine Extended Release(XR)

Early Phase 1

Terminated

Conditions: Social Anxiety Disorder

Interventions: Drug: Quetiapine XR
Drug: Placebo

First Posted Date: 2008-02-04

Last Posted Date: 2014-08-01

Lead Sponsor: Duke University

Target Recruit Count: 55

Registration Number: NCT00606541

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

A Randomized Trial of Remote Monitoring of Implantable Cardioverter Defibrillators Versus Quarterly Device Interrogations in Clinic

Not Applicable

Completed

Conditions: Tachycardia, Ventricular
Ventricular Fibrillation

Interventions: Other: Methods for monitoring patients with ICD's

First Posted Date: 2008-02-04

Last Posted Date: 2014-07-14

Lead Sponsor: Duke University

Target Recruit Count: 151

Registration Number: NCT00606567

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Total Body Irradiation With Fludarabine Followed by Combined Umbilical Cord Blood (UCB) Transplants

Phase 1

Completed

Conditions: Myelodysplasia
Hodgkin's Disease
Myelofibrosis
Lymphoma
Solid Tumors
Myeloma
Leukemia

Interventions: Procedure: Total Body Irradiation with Fludarabine in UCB Transplants

First Posted Date: 2008-02-04

Last Posted Date: 2014-05-16

Lead Sponsor: Duke University

Target Recruit Count: 40

Registration Number: NCT00606437

Locations: 🇺🇸
Duke University Health System, Durham, North Carolina, United States

DNA/RNA Analysis of Blood and Skeletal Muscle in Patients Undergoing Cardiac Resynchronization Therapy (CRT)

Completed

Conditions: Cardiomyopathy (Ischemic or Non-Ischemic)

First Posted Date: 2008-01-25

Last Posted Date: 2016-01-20

Lead Sponsor: Duke University

Target Recruit Count: 30

Registration Number: NCT00600392

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Phase 2

Completed

Conditions: Glioblastoma
Gliosarcoma
Brain Tumor

Interventions: Drug: Avastin
Drug: Temozolomide
Radiation: Radiation Therapy (XRT)
Drug: Irinotecan

First Posted Date: 2008-01-18

Last Posted Date: 2014-05-07

Lead Sponsor: Duke University

Target Recruit Count: 125

Registration Number: NCT00597402

Locations: 🇺🇸
Duke University Health System, Durham, North Carolina, United States

Ph. 2 Sorafenib + Protracted Temozolomide in Recurrent GBM

Phase 2

Completed

Conditions: Recurrent Glioblastoma Multiforme

Interventions: Drug: Sorafenib and Temozolomide

First Posted Date: 2008-01-18

Last Posted Date: 2013-06-24

Lead Sponsor: Duke University

Target Recruit Count: 32

Registration Number: NCT00597493

Locations: 🇺🇸
Duke University Health System, Durham, North Carolina, United States

A Phase I/Expansion Study of Dasatinib

Phase 1

Terminated

Conditions: Refractory Solid Tumors
Pancreatic Adenocarcinoma

Interventions: Drug: gemcitabine
Drug: dasatinib

First Posted Date: 2008-01-18

Last Posted Date: 2015-09-07

Lead Sponsor: Duke University

Target Recruit Count: 30

Registration Number: NCT00598091

Locations: 🇺🇸
UNC Lineberger, Comprehensive Cancer Center, Chapel Hill, North Carolina, United States
🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸
Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States

Alcohol in the Treatment of Obesity

Not Applicable

Terminated

Conditions: Obesity, Weight Loss, Alcohol Drinking

Interventions: Other: white wine

First Posted Date: 2008-01-15

Last Posted Date: 2013-07-25

Lead Sponsor: Duke University

Target Recruit Count: 18

Registration Number: NCT00594074

Locations: 🇺🇸
Structure House, LLC, Durham, North Carolina, United States

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