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Rein Therapeutics

Ownership
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Employees
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Market Cap
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Website
Introduction

Aileron Therapeutics, Inc. is a clinical stage biopharmaceutical company, which engages in the development and commercialization of a novel class of therapeutics for the treatment of cancer and other diseases. It focuses on its lead product candidate, ALRN-6924, which is a cell-permeating peptide that disrupts the interaction of p53 suppressors MDM2 and MDMX with tumor suppressor p53 to reactivate tumor suppression in non-mutant, or wild-type, p53 cancers. The company was founded by Gregory L. Verdine, Rosana Kapeller, Huw M. Nash, Joseph A. Yanchik III, and Loren David Walensky on August 6, 2001 and is headquartered in Austin, TX.

Clinical Trials

2

Active:1
Completed:1

Trial Phases

2 Phases

Phase 1:1
Phase 2:1

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (2 trials with phase data)• Click on a phase to view related trials

Phase 1
1 (50.0%)
Phase 2
1 (50.0%)

A Phase 2 Study of LTI-03 in Patients With Idiopathic Pulmonary Fibrosis

Phase 2
Active, not recruiting
Conditions
Idiopathic Pulmonary Fibrosis (IPF)
Interventions
Device: Dry Powder Inhaler
Drug: Placebo
First Posted Date
2025-05-13
Last Posted Date
2025-06-17
Lead Sponsor
Rein Therapeutics
Target Recruit Count
120
Registration Number
NCT06968845
Locations
🇺🇸

The Lung Research Center, LLC, Chesterfield, Missouri, United States

🇺🇸

El Paso Pulmonary Association, El Paso, Texas, United States

A Study to Evaluate LTI-03 in Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF) Patients

Phase 1
Completed
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Drug: Placebo
First Posted Date
2023-07-20
Last Posted Date
2025-04-24
Lead Sponsor
Rein Therapeutics
Target Recruit Count
24
Registration Number
NCT05954988
Locations
🇺🇸

University of Alabama, Birmingham, Alabama, United States

🇺🇸

University of Southern California, Los Angeles, California, United States

🇺🇸

Cedars Sinai Medical Center, Los Angeles, California, United States

and more 4 locations

News

Aileron Therapeutics Rebrands as Rein Therapeutics, Focuses on Fibrosis Therapies

Aileron Therapeutics has rebranded to Rein Therapeutics, signaling a sharpened focus on developing treatments for orphan pulmonary and fibrotic diseases.

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