MedPath

Protara Therapeutics

Protara Therapeutics logo
🇺🇸United States
Ownership
Public
Established
2017-01-01
Employees
27
Market Cap
$42.4M
Website
http://www.protaratx.com
Introduction

Protara Therapeutics, Inc. is a clinical-stage company engaged in developing treatments for rare and specialty diseases with significant unmet needs. Its current development programs focus on the treatment of rare diseases in structural and connective tissues and rare hepatology, gastrointestinal, and metabolic disorders. The company was founded by Jesse Shefferman and Jacqueline Zummo in March 2006 and is headquartered in New York, NY.

Clinical Trials

7

Active:0
Completed:3

Trial Phases

2 Phases

Phase 1:2
Phase 2:3

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (5 trials with phase data)• Click on a phase to view related trials

Phase 2
3 (60.0%)
Phase 1
2 (40.0%)

Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support

Phase 2
Not yet recruiting
Conditions
Choline Deficiency
Liver Injury
Interventions
Drug: Choline Chloride for Injection
Drug: Placebo
First Posted Date
2025-04-04
Last Posted Date
2025-04-04
Lead Sponsor
Protara Therapeutics
Target Recruit Count
144
Registration Number
NCT06910943

Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

Phase 2
Recruiting
Conditions
Non-muscle Invasive Bladder Cancer
Interventions
First Posted Date
2023-07-18
Last Posted Date
2025-04-29
Lead Sponsor
Protara Therapeutics
Target Recruit Count
127
Registration Number
NCT05951179
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Urology Group of Southern California, Los Angeles, California, United States

🇺🇸

University of California Irvine Medical Center, Orange, California, United States

and more 24 locations

Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age

Phase 2
Recruiting
Conditions
Lymphatic Malformation
Interventions
First Posted Date
2023-05-23
Last Posted Date
2024-12-27
Lead Sponsor
Protara Therapeutics
Target Recruit Count
38
Registration Number
NCT05871970
Locations
🇺🇸

Oregon Health & Science University, Portland, Oregon, United States

🇺🇸

Children's Hospital of Alabama, Birmingham, Alabama, United States

🇺🇸

Arkansas Children's Hospital/UAMS, Little Rock, Arkansas, United States

and more 7 locations

Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults with High-grade Non-muscle Invasive Bladder Cancer (Phase 1b)

Phase 1
Completed
Conditions
Non-muscle Invasive Bladder Cancer
Interventions
First Posted Date
2021-10-20
Last Posted Date
2025-01-27
Lead Sponsor
Protara Therapeutics
Target Recruit Count
10
Registration Number
NCT05085990
Locations
🇺🇸

USC Norris Cancer Center, Los Angeles, California, United States

🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Tulane Medical Center (TMC) - Clinic/Outpatient Facility, New Orleans, Louisiana, United States

and more 6 locations

Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults with High-grade Non-muscle Invasive Bladder Cancer (Phase 1a)

Phase 1
Completed
Conditions
Non-muscle Invasive Bladder Cancer
Interventions
First Posted Date
2021-10-20
Last Posted Date
2025-01-27
Lead Sponsor
Protara Therapeutics
Target Recruit Count
12
Registration Number
NCT05085977
Locations
🇺🇸

USC Norris Cancer Center, Los Angeles, California, United States

🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Tulane Medical Center, New Orleans, Louisiana, United States

and more 10 locations
  • Prev
  • 1
  • 2
  • Next

News

Protara Therapeutics Appoints William Conkling as Chief Commercial Officer to Lead Commercialization Strategy

Protara Therapeutics has appointed William Conkling as Chief Commercial Officer, bringing over two decades of experience in developing and commercializing cancer and rare disease therapeutics.

Biotech Leadership Shuffle Continues as Industry Navigates Transformation in Q2 2025

Novo Nordisk undergoes significant executive restructuring following the departure of EVP Camilla Sylvest, with rare disease leader Ludovic Helfgott taking over expanded commercial strategy responsibilities.

Protara Therapeutics Reports 72% Complete Response Rate in NMIBC Trial, Secures $100M Funding

Protara Therapeutics' TARA-002 demonstrates strong efficacy in Phase 2 ADVANCED-2 trial for non-muscle invasive bladder cancer, achieving 72% six-month complete response rate across all BCG exposure levels.

Protara Therapeutics Announces Key Milestones for 2025, Including NMIBC and LM Data

Protara Therapeutics anticipates mid-2025 data from the ADVANCED-2 trial of TARA-002 in non-muscle invasive bladder cancer (NMIBC) patients, building on positive six-month results.

TARA-002 and Cretostimogene Grenadenorepvec Show Promise in Bladder Cancer

• Protara Therapeutics' TARA-002 demonstrated a 72% complete response rate in non-muscle invasive bladder cancer patients, regardless of prior BCG exposure. • In BCG-unresponsive patients, TARA-002 achieved a 100% complete response rate at six months, highlighting its potential in a registrational cohort. • CG Oncology's cretostimogene grenadenorepvec showed a 74.5% complete response rate in BCG-unresponsive patients, with a median duration of response exceeding 27 months. • Both TARA-002 and cretostimogene grenadenorepvec exhibited favorable tolerability profiles, with minimal treatment-related adverse events.

Protara's TARA-002 Shows Promise in Phase 2 Trial for Bladder Cancer

Protara Therapeutics' TARA-002 demonstrated a 72% six-month complete response rate in NMIBC patients across various BCG exposure statuses.

Protara Therapeutics Presents Promising Interim Data on TARA-002 for Bladder Cancer

Protara Therapeutics is presenting interim Phase 2 data for TARA-002 in non-muscle invasive bladder cancer (NMIBC) at the SUO annual meeting.

Protara Therapeutics Announces Progress in TARA-002 and IV Choline Chloride Programs

Protara Therapeutics' TARA-002 shows promise in NMIBC treatment, with ADVANCED-2 trial results expected in Q4 2024, and positive interim data in Lymphatic Malformations.

Protara Therapeutics Receives FDA Fast Track Designation for IV Choline Chloride

Protara Therapeutics' IV Choline Chloride receives FDA Fast Track designation for treating choline deficiency in parenteral support patients.

© Copyright 2025. All Rights Reserved by MedPath