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OPTHEA LIMITED

🇦🇺Australia
Ownership
-
Employees
-
Market Cap
-
Website

Clinical Trials

29

Active:19
Completed:3

Trial Phases

3 Phases

Phase 1:21
Phase 2:1
Phase 3:7

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (29 trials with phase data)• Click on a phase to view related trials

Phase 1
21 (72.4%)
Phase 3
7 (24.1%)
Phase 2
1 (3.4%)

OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD)

Phase 3
Terminated
Conditions
Neovascular Age-related Macular Degeneration
Interventions
Biological: 2.0 mg OPT-302
Procedure: Sham
First Posted Date
2021-02-17
Last Posted Date
2025-07-22
Lead Sponsor
Opthea Limited
Target Recruit Count
986
Registration Number
NCT04757610
Locations
🇬🇧

ShORe Investigational Site, London, United Kingdom

🇧🇷

ShORe Investigational site, Blumenau, Santa Catarina, Brazil

🇺🇸

ShORe Investiagtional Site, Poway, California, United States

and more 1 locations

OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)

Phase 3
Terminated
Conditions
Neovascular Age-related Macular Degeneration
Interventions
Biological: 2.0 mg OPT-302
Biological: 2.0 aflibercept
Procedure: Sham
First Posted Date
2021-02-17
Last Posted Date
2025-08-05
Lead Sponsor
Opthea Limited
Target Recruit Count
998
Registration Number
NCT04757636
Locations
🇬🇧

COAST Investigational Site, London, United Kingdom

🇺🇸

COAST Investigational site, Shirley, New York, United States

A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema

Phase 1
Completed
Conditions
Diabetic Macular Edema
Interventions
Other: Sham intravitreal injection
First Posted Date
2018-01-11
Last Posted Date
2025-04-22
Lead Sponsor
Opthea Limited
Target Recruit Count
153
Registration Number
NCT03397264
Locations
🇱🇻

Opthea Investigational Site, Riga, Latvia

A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD

Phase 2
Completed
Conditions
Neovascular Age-related Macular Degeneration
First Posted Date
2017-11-17
Last Posted Date
2021-01-12
Lead Sponsor
Opthea Limited
Target Recruit Count
366
Registration Number
NCT03345082
Locations
🇬🇧

Opthea Investigational Site, Wolverhampton, United Kingdom

🇺🇸

Opthea Study Site, Sacramento, California, United States

🇵🇱

Opthea Investigationa Site, Lublin, Poland

Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentis™ in Patients With Wet AMD

Phase 1
Completed
Conditions
Eye Diseases
Macular Degeneration
Retinal Diseases
Retinal Degeneration
Neovascularization, Pathologic
Interventions
Drug: Lucentis™
First Posted Date
2015-09-07
Last Posted Date
2017-11-06
Lead Sponsor
Opthea Limited
Target Recruit Count
51
Registration Number
NCT02543229
Locations
🇺🇸

Opthea Investigative Site, Willow Park, Texas, United States

News

Sozinibercept Shows Promise in Wet AMD Treatment as Opthea's Pivotal Trials Progress

Opthea's sozinibercept (OPT-302) demonstrates potential to enhance visual outcomes in wet age-related macular degeneration patients without competing with standard anti-VEGF-A therapies.

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