WORLD HEALTH ORGANIZATION

President-elect Trump praises polio vaccine, while lawyer Aaron Siri petitions FDA to revoke approval, aligning with Trump's HHS pick, RFK Jr. The FDA reviews Siri's petition, questioning vaccine safety without placebo trials. Polio vaccination is hailed as a public health triumph, though critics distort its risks.

Kenya launched a 5-day MDA campaign in Kakamega to eliminate intestinal worms and bilharzia, targeting 1.8 million people with support from WHO, Amref Health Africa, AIHD, PATH, and The END Fund. Over 4,250 Community Health Promoters will administer drugs to ensure maximum coverage. NTDs, affecting over 1 billion globally, contribute to 534,000 annual deaths and cost developing economies billions. Kenya faces significant NTD burden, including LF, schistosomiasis, and trachoma, affecting over 25 million. The government has made progress in managing NTDs, including Guinea Worm elimination in 2017. Kakamega County has achieved notable outcomes, treating over 100,000 for LF and schistosomiasis, and reducing trachoma prevalence by 20%. The NTD Master Plan 2023-2027 provides a strategic framework for prevention, control, elimination, and eradication of targeted NTDs. Strengthened Primary Health Care in Kakamega through 12 PCNs has improved immunization coverage by 15% and enhanced referral and outreach services. The roll-out of ECHIS has digitized over 30,000 patient records, improving efficiency and data accuracy.

References include WHO on ageing, Rudolph the Red-Nosed Reindeer, estimands framework, research question driving study methods, clarity in clinical trial reports, population-level summary measures, binary outcome data analysis, COVID-19 trial questions, estimands in clinical trials, handling missing data, and hypothetical estimands in trials.

The project combines BRICHOS protein effects with nerve growth factor (NGF) to study Alzheimer's pathology. Goals include testing BRICHOS-NGF transport efficiency, its function in mouse models, and potential application in patients. The research team is grateful for the grant enabling efficient project execution.

China's top drug regulator approved clinical trials of a Sinopharm-developed mpox vaccine, which has shown safety and effectiveness in preclinical research. Another Sinopharm subsidiary and the Institute of Microbiology are also researching mpox vaccines. The WHO declared mpox a global health emergency in August, with China reporting 46 infections in September and 38 in October.

Aaron Siri filed a petition to revoke the polio vaccine's federal approval, questioning its safety and efficacy. The vaccine, invented in 1955, eradicated polio in the U.S. and has prevented millions of cases globally. Siri seeks a double-blind trial and label changes, also targeting 13 other vaccines for aluminum content.

The cell free DNA (cfDNA) testing market is projected to grow from $7.07 billion in 2023 to $20.63 billion by 2028, driven by advances in liquid biopsy, personalized medicine, and cancer prevalence. Key trends include liquid biopsy adoption, NGS advancements, and AI integration.