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Durect

Ownership
-
Employees
58
Market Cap
-
Website
Introduction

DURECT Corp. focuses on advancing novel and potentially lifesaving investigational therapies derived from its Epigenetic Regulator Program. Its pipeline is called DUR-928, an endogenous sulfated oxysterol and an epigenetic regulator. The company was founded by James E. Brown and Felix Theeuwes on February 6, 1998 and is headquartered in Cupertino, CA.

Clinical Trials

15

Active:0
Completed:13

Trial Phases

2 Phases

Phase 2:12
Phase 3:2

Drug Approvals

0

Drug Approvals

No drug approvals found

This company may not have drug approvals in our database

Clinical Trials

Distribution across different clinical trial phases (14 trials with phase data)• Click on a phase to view related trials

Phase 2
12 (85.7%)
Phase 3
2 (14.3%)

A Phase 2b Study in Subjects With Alcoholic Hepatitis to Evaluate Safety and Efficacy of DUR-928 Treatment

Phase 2
Completed
Conditions
Alcoholic Hepatitis
Interventions
Drug: DUR-928 30 mg
Drug: Placebo+ Standard of Care (SOC)
Drug: DUR-928 90 mg
First Posted Date
2020-09-24
Last Posted Date
2024-02-26
Lead Sponsor
Durect
Target Recruit Count
307
Registration Number
NCT04563026
Locations
🇺🇸

University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama, United States

🇺🇸

Mayo Clinic Hospital, Phoenix, Arizona, United States

🇺🇸

Southern California Research Center, Coronado, California, United States

and more 65 locations

DUR-928 in Subjects With SARS-CoV-2 With Acute Lung, Liver or Kidney Injury

Phase 2
Terminated
Conditions
SARS-CoV-2
Interventions
Drug: Placebo
First Posted Date
2020-06-25
Last Posted Date
2022-08-05
Lead Sponsor
Durect
Target Recruit Count
2
Registration Number
NCT04447404
Locations
🇺🇸

Site 03, Newark, New Jersey, United States

Safety and Efficacy Study of DUR-928 Topical Solution in Subjects With Plaque Psoriasis

Phase 2
Completed
Conditions
Plaque Psoriasis
Interventions
Drug: DUR-928 Topical Solution
Drug: Vehicle Topical Solution
First Posted Date
2019-02-12
Last Posted Date
2022-09-02
Lead Sponsor
Durect
Target Recruit Count
25
Registration Number
NCT03837743
Locations
🇺🇸

Site 01, San Diego, California, United States

🇺🇸

Site 04, Miami, Florida, United States

🇺🇸

Site 05, Tampa, Florida, United States

and more 2 locations

A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis

Phase 2
Completed
Conditions
Alcoholic Hepatitis
Interventions
Drug: DUR-928 90 mg
Drug: DUR-928 150 mg
Drug: DUR-928 30 mg
First Posted Date
2018-02-14
Last Posted Date
2022-12-14
Lead Sponsor
Durect
Target Recruit Count
19
Registration Number
NCT03432260
Locations
🇺🇸

DURECT Study Site 0001, San Diego, California, United States

🇺🇸

DURECT Study Site 007, Miami, Florida, United States

🇺🇸

DURECT Study Site 0004, Atlanta, Georgia, United States

and more 4 locations

A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC)

Phase 2
Terminated
Conditions
Primary Sclerosing Cholangitis
Interventions
First Posted Date
2018-01-09
Last Posted Date
2022-10-17
Lead Sponsor
Durect
Target Recruit Count
5
Registration Number
NCT03394781
Locations
🇺🇸

California Pacific Medical Center, San Francisco, California, United States

🇺🇸

Mayo Clinic Florida, Jacksonville, Florida, United States

🇺🇸

Southern Therapy and Advanced Research, Jackson, Mississippi, United States

and more 1 locations
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