Clinical Trials
27
Trial Phases
2 Phases
Drug Approvals
0
Drug Approvals
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Clinical Trials
Distribution across different clinical trial phases (27 trials with phase data)• Click on a phase to view related trials
Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults
- Conditions
- Malaria Falciparum
- Interventions
- Biological: PfSPZ-LARC2 VaccineOther: Normal Saline (Placebo)Biological: PfSPZ Challenge (NF54)
- First Posted Date
- 2025-03-06
- Last Posted Date
- 2025-03-06
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 58
- Registration Number
- NCT06862453
- Locations
- 🇩🇪
University of Tubingen, Wilhelmstraße 27, Tubingen, Germany
Age De-escalation Safety Trial of PfSPZ-LARC2 Vaccine in Burkina Faso
- Conditions
- Malaria FalciparumMalaria Infection
- Interventions
- Biological: PfSPZ-LARC2 VaccineBiological: Normal Saline (Placebo)
- First Posted Date
- 2024-10-22
- Last Posted Date
- 2025-04-09
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 75
- Registration Number
- NCT06652737
- Locations
- 🇧🇫
Groupe de Recherche Action en Santé (GRAS) / Unité de Recherche Clinique de Sabou, Ouagadougou, Burkina Faso
A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI
- Conditions
- Malaria,FalciparumMalaria
- Interventions
- First Posted Date
- 2022-11-03
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 31
- Registration Number
- NCT05604521
- Locations
- 🇺🇸
University of Maryland, Baltimore, Center for Vaccine Development and Global Health, Baltimore, Maryland, United States
Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults
- Conditions
- Malaria
- First Posted Date
- 2021-07-19
- Last Posted Date
- 2022-07-18
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 54
- Registration Number
- NCT04966871
- Locations
- 🇺🇸
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
PfSPZ Vaccine Trial in Malian Children
- Conditions
- Malaria,FalciparumMalaria
- First Posted Date
- 2021-06-25
- Last Posted Date
- 2024-02-07
- Lead Sponsor
- Sanaria Inc.
- Target Recruit Count
- 290
- Registration Number
- NCT04940130
- Locations
- 🇲🇱
Malaria Research and Training Center, Bamako, Mali
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News
Experimental Malaria Vaccine Shows Lasting Protection in Clinical Trials
An experimental malaria vaccine, PfSPZ Vaccine, demonstrated significant protection against parasite infection and clinical malaria for up to two years in healthy Malian adults.