相关临床试验
29
4 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1965
进行中（未招募）
1
3.5%
已完成
17
58.6%
Enrolling By Invitation
1
3.5%
尚未招募
2
6.9%
招募中
1
3.5%
Unknown
7
24.1%
暂无批准数据
- A systematic review of over 1.9 million people across 23 studies found ADHD is associated with an almost 50% increase in overall gastrointestinal symptoms. - Specific associations were stronger, with nearly double the odds of constipation, a 58% increase in irritable bowel syndrome, and more than four times the odds of encopresis. - Published in the Journal of Attention Disorders, the analysis is the first systematic review focused specifically on gastrointestinal symptoms in ADHD. - Researchers stress the findings show association rather than causation and call for work to separate biological factors from medication effects.
- Researchers from the University of Warwick and Monash University found that the bacterial antibiotic gladiolin can switch Candida albicans from its invasive hyphae form back to a harmless yeast state. - Gladiolin works by altering fungal metabolism, causing the pathogen to burn through glucose faster and depriving hyphae of the fuel needed to sustain tissue invasion. - The study, published in Current Biology, builds on a 2024 discovery showing gladiolin also boosts the effectiveness of the antifungal drug amphotericin B. - The findings suggest a "disarm rather than kill" strategy that could help existing drugs defeat drug-resistant biofilms while enabling lower, less toxic antifungal doses.
- Researchers at the University of Warwick and Monash University have revealed how bacterial enzymes use 'docking domains' to assemble multiple variants of powerful anti-cancer compounds through a combinatorial biosynthesis mechanism. - The study, published in Nature Communications, identifies a conserved connection point that allows different enzyme partners to mix and match, explaining how bacteria generate structural diversity in HDAC inhibitors like Romidepsin. - The team also identified the previously mysterious biosynthetic pathway for FR-901375, a chemically related depsipeptide HDAC inhibitor, by locating its gene cluster in Pseudomonas chlororaphis subsp. piscium. - Prof. Greg Challis states the discovery provides a blueprint to design synthetic pathways for new anti-cancer drug candidates with superior potency, improved selectivity, and fewer side effects.
- Medherant's TEPI Patch successfully restored testosterone blood levels to normal pre-menopausal ranges in post-menopausal women during Phase 1 clinical testing at Hammersmith Medicines Research in London. - The innovative transdermal patch technology offers superior comfort and adhesion compared to existing hormone delivery methods, addressing a significant unmet need in menopause treatment. - The company has received regulatory approval from MHRA and Research Ethics Committee to proceed with a multiple-dose pharmacokinetic study targeting hypoactive sexual desire disorder in post-menopausal women. - Despite recommendations in NICE Menopause Guidelines, no approved testosterone patch product currently exists for women, making this development potentially first-in-class.
- MIT researchers used generative AI to design two novel antibiotics capable of killing drug-resistant gonorrhea and MRSA in laboratory and animal tests. - The AI system analyzed 36 million compounds using two innovative approaches to create completely new molecular structures distinct from existing antibiotics. - While promising, only two of 80 AI-generated gonorrhea treatments could be synthesized, highlighting manufacturing challenges before human clinical trials can begin. - Experts believe this breakthrough could herald a "second golden age" of antibiotic discovery in the fight against antimicrobial resistance.
