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Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum

Phase 1
Terminated
Conditions
Thoracic Sarcomas
Thorasic Cancers
Sarcoma
Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura
Melanoma
Interventions
Biological: H1299 cell lysates
Biological: Iscomatrix adjuvant
Drug: Cyclophosphamide
Drug: Celecoxib
First Posted Date
2014-02-04
Last Posted Date
2022-01-26
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
21
Registration Number
NCT02054104
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Recruiting
Conditions
Esophageal Cancers NOS
Lung Cancer NOS
Malignant Pleural Mesotheliomas NOS
Thoracic Cancers
Cancers of Non Thoracic Origin With Metastases to the Lungs or Pleura
First Posted Date
2005-10-20
Last Posted Date
2024-12-17
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
1100
Registration Number
NCT00242723
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies

Phase 1
Completed
Conditions
Advanced Esophageal Cancers
Pleural Mesotheliomas
Primary Small Cell Lung Cancers
Non-Small-Cell Lung Carcinoma
Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura
Interventions
Drug: Decitabine
Biological: Depsipeptide
Drug: Celecoxib
First Posted Date
2002-05-22
Last Posted Date
2019-09-30
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
34
Registration Number
NCT00037817
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

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