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A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Phase 3
Recruiting
Conditions
Glioblastoma
Brain Tumor
GBM
Brain Neoplasms, Adult, Malignant
Interventions
First Posted Date
2024-04-29
Last Posted Date
2024-06-24
Lead Sponsor
Ivy Brain Tumor Center
Target Recruit Count
450
Registration Number
NCT06388733
Locations
🇺🇸

Ivy Brain Tumor Center, Phoenix, Arizona, United States

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Phase 2
Recruiting
Conditions
Brain Tumor, Primary
CNS Cancer
Brain Metastases
Brain Neoplasms
Multiple Sclerosis
Acoustic Neuroma
CNS Lesion
CNS Metastases
Central Nervous System (CNS) Lesions
Neurofibroma
Interventions
Drug: RVP-001
First Posted Date
2024-03-21
Last Posted Date
2024-10-07
Lead Sponsor
Reveal Pharmaceuticals Inc.
Target Recruit Count
24
Registration Number
NCT06322342
Locations
🇺🇸

Brigham & Women's Hospital, Boston, Massachusetts, United States

🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 1 locations

Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors

Not Applicable
Recruiting
Conditions
Brain Neoplasms
Interventions
Procedure: Intracranial Catheter Placement
Procedure: Lumbar Puncture
Procedure: Biopsy
Procedure: Biospecimen Collection
Procedure: Computed Tomography
First Posted Date
2024-03-21
Last Posted Date
2024-03-26
Lead Sponsor
Mayo Clinic
Target Recruit Count
10
Registration Number
NCT06322602
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

Recruiting
Conditions
Glioblastoma Multiforme of Brain
Brain Neoplasms
Recurrent Adult Brain Tumor
Brain Neoplasms, Adult
Recurrent Glioblastoma
Glioblastoma, IDH-wildtype
Glioblastoma
Astrocytoma, Malignant
Brain Neoplasms, Adult, Malignant
Interventions
Procedure: Awake mapping under local anesthesia
Procedure: Resection under general anesthesia without mapping
Procedure: Asleep mapping under general anesthesia
First Posted Date
2024-02-22
Last Posted Date
2024-02-22
Lead Sponsor
Erasmus Medical Center
Target Recruit Count
225
Registration Number
NCT06273176
Locations
🇳🇱

Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

🇩🇪

Universitätsklinikum Heidelberg, Heidelberg, Germany

🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

and more 5 locations

Clinical Application of the Prototype J-PET Device

Completed
Conditions
Neuroendocrine Tumors
Neurodegenerative Diseases
Brain Neoplasms
Interventions
Diagnostic Test: Positron-Emission Tomography Imaging
First Posted Date
2024-01-18
Last Posted Date
2024-01-18
Lead Sponsor
Jagiellonian University
Target Recruit Count
10
Registration Number
NCT06211803
Locations
🇵🇱

Department of Nuclear Medicine, Warsaw, Mazowieckie, Poland

Guided Meditation During Radiation Therapy for Brain Tumors

Not Applicable
Recruiting
Conditions
Brain Neoplasms
Interventions
Behavioral: 5-Minute, Audio-Recorded Guided Mediation Practice
First Posted Date
2023-12-11
Last Posted Date
2024-11-14
Lead Sponsor
University of Utah
Target Recruit Count
30
Registration Number
NCT06165653
Locations
🇺🇸

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Phase I Study of JYP0322 in ROS1 Fusion-Positive Solid Tumors

Phase 1
Recruiting
Conditions
Protein Kinase Inhibitors
Other Protocol Specified Criteria
Lung Neoplasms
Brain Neoplasms
Interventions
Drug: JYP0322 50 mg qd
Drug: JYP0322 100 mg qd
Drug: JYP0322 200 mg qd
Drug: JYP0322 100 mg bid
Drug: JYP0322 150 mg bid
Drug: JYP0322 200 mg bid
First Posted Date
2023-11-13
Last Posted Date
2024-11-20
Lead Sponsor
Guangzhou JOYO Pharma Co., Ltd
Target Recruit Count
54
Registration Number
NCT06128148
Locations
🇨🇳

Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

Recruiting
Conditions
High-grade Glioma
Glioblastoma, IDH-wildtype
Glioblastoma Multiforme, Adult
Astrocytoma, Grade III
Brain Neoplasm, Primary
Glioblastoma, IDH-mutant
Astrocytoma, Grade IV
Glioblastoma
Brain Neoplasms
Brain Neoplasms, Adult
Interventions
Procedure: Maximal safe resection
Procedure: Supramaximal resection
First Posted Date
2023-11-07
Last Posted Date
2024-02-22
Lead Sponsor
Jasper Gerritsen
Target Recruit Count
784
Registration Number
NCT06118723
Locations
🇨🇭

Inselspital Universitätsspital Bern, Bern, Switzerland

🇩🇪

Technical University Munich, Munich, Bavaria, Germany

🇺🇸

University of California, San Francisco (UCSF), San Francisco, California, United States

and more 5 locations

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics

Recruiting
Conditions
Coronary Artery Disease
Heart Valve Diseases
Myocarditis
Cardiomyopathies
Hemorrhagic Cerebrovascular Disease
Aortic Dissection
Hypertension
Arrhythmias, Cardiac
Brain Neoplasms
Heart Neoplasms
Interventions
Other: Observational; No Interventions were given.
First Posted Date
2023-08-21
Last Posted Date
2024-07-12
Lead Sponsor
First Affiliated Hospital Xi'an Jiaotong University
Target Recruit Count
25000
Registration Number
NCT06001073
Locations
🇨🇳

First Affiliated Hospital of Xian Jiantong University, Xi'an, Shaanxi, China

EMERGENCE AGITATION After Premedication IN PAEDIATRIC MAGNETIC RESONANCE IMAGING: A RETROSPECTIVE COHORT STUDY

Completed
Conditions
Growth Retardation
Autism Spectrum Disorder
Brain Pathology
Premedication
Brain Neoplasms
First Posted Date
2023-07-14
Last Posted Date
2023-07-17
Lead Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Target Recruit Count
100
Registration Number
NCT05946928
Locations
🇮🇹

Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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