West Virginia Approves Study Comparing Buprenorphine and Methadone for Opioid Use Disorder
West Virginia lawmakers passed a bill allowing clinical trials on opioid use disorder treatments, specifically comparing buprenorphine and methadone.
European Consortium Secures €2.5 Million to Develop Predictive Biomarker Test for Immunotherapy Response
A European consortium led by OncoHost has been awarded €2.5 million from the EIC Transition Programme to develop NeutroFlow, a diagnostic test predicting patient response to immune checkpoint inhibitors across five cancer types.
Liverpool Researchers Trial Oral Treatment for Deadly Leishmaniasis Disease
A groundbreaking clinical trial for visceral leishmaniasis is underway in Liverpool, testing an oral drug (DNDi-6899) that could replace current painful injection treatments requiring hospitalization.
Dermatology Experts Highlight Advances in Treatment and Clinical Trial Diversity
Experts at the Skin of Color Update 2024 emphasized the importance of diversity in clinical trials to address health disparities and improve data for all patient populations.
Psilocybin Shows Promise in Easing End-of-Life Distress
Psilocybin-assisted therapy is emerging as a potential treatment for anxiety, depression, and existential distress in patients facing terminal illnesses.
Framework Proposed for N-of-1 Trials of Individualized Gene Therapies
Researchers propose a framework for N-of-1 trials focusing on individualized gene-targeted therapies for rare genetic diseases, addressing the challenges in evaluating treatments for single patients.
Arch Biopartners Receives Ethics Approval for Phase II Trial of LSALT Peptide in Calgary
Arch Biopartners Inc. has announced that the University of Calgary’s Conjoint Health Research Ethics Board has approved a Phase II trial for LSALT peptide, aimed at preventing and treating cardiac surgery-associated acute kidney injury (CS-AKI). The trial, which is also recruiting patients in Turkey, seeks to evaluate the effectiveness of LSALT peptide in reducing AKI incidents post-cardiac surgery.
North American Hospitals Spearhead Clinical Trials for Trigeminal Neuralgia
Leading hospitals across North America are actively engaged in clinical trials to find effective treatments for trigeminal neuralgia, a condition causing severe facial pain.
NeoGASTRIC Trial Assesses Feeding Methods for Premature Infants
The NeoGASTRIC trial is evaluating whether routine measurement of gastric residual volumes affects the time it takes premature babies to reach full feeding volumes.
Tirzepatide Shows Favorable Muscle Composition Changes in Type 2 Diabetes Patients, SURPASS-3 Trial Analysis Reveals
Post-hoc analysis of Lilly's SURPASS-3 trial reveals tirzepatide treatment in type 2 diabetes patients leads to muscle volume changes proportional to weight loss, with greater than expected reductions in muscle fat infiltration.
ACCC Fall 2024: Innovations in Clinical Trial Access, Patient Care, and Treatment Authorization
The Ohio State University Cancer Center's automated informatics program has achieved a 21.9% increase in biosimilar utilization while streamlining prior authorization processes, earning an Innovator Award at ACCC 2024.
Novel Screening Technologies Enter Clinical Trial to Detect Silent Esophageal Precancer
University Hospitals and Case Western Reserve University launch an $8 million NIH-funded clinical trial to evaluate EsoCheck and EsoGuard technologies for detecting Barrett's Esophagus in non-GERD patients.
FDA's Approval of Kisunla Faces Scrutiny Over Advisory Committee Conflicts of Interest
An investigation reveals that a significant number of FDA advisory committee members who recommended Kisunla's approval had financial ties to Eli Lilly and other companies developing anti-amyloid drugs.
Blackstone's Acquisition of I'rom Group Approved with Divestiture of CMAX Clinical Research
The ACCC has approved Blackstone's acquisition of I'rom Group Co Limited, conditional on the divestiture of CMAX Clinical Research Pty Ltd.
Evolution of Managed Care: Three Decades of Healthcare Transformation and Future Outlook
Managed care has evolved significantly over 30 years, bringing advances in prevention, guidelines implementation, and quality metrics, with vaccination rates rising from 50% to over 90% before the COVID-19 era.
Evolution of PNH Treatment: New Therapies Transform Management of Rare Blood Disorder
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare but potentially fatal blood disorder affecting approximately 38 per million people, with delayed diagnosis common due to its complex symptoms and manifestations.
DAV132 Adsorbent Does Not Interfere with Plasma Concentrations of Key Antibiotics
A randomized, controlled study (CL-006) found that DAV132, a colon-targeted adsorbent, did not significantly alter plasma concentrations of ceftriaxone, piperacillin, tazobactam, ceftazidime, and avibactam.
Manali Kamdar's Contributions to Lymphoma Treatment Research
Dr. Manali Kamdar, Clinical Director of Lymphoma Services at the University of Colorado Cancer Center, focuses on novel therapies for non-Hodgkin lymphoma, participating in significant clinical trials like TRANSFORM and TRANSCEND-NHL-001.
Robert Salata, Leading Infectious Disease Expert, Dies at 72
Dr. Robert Salata, a distinguished figure in infectious disease research and education at University Hospitals and Case Western Reserve University, passed away on August 26 at the age of 72.
Jackson Laboratory's MCGI Studies Impact of Genomic Tumor Boards and HER2 in Cancer Care
The Maine Cancer Genomics Initiative (MCGI) is expanding access to precision medicine for oncologists in rural and underserved areas.