High-flow Nasal Cannula Oxygen Therapy for Ischemic Stroke Patients With Dysphagia and Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- apnea-hypopnea index
研究概览
简要总结
High flow nasal cannula (HFNC) ventilation therapy was found to improve the severity of obstructive sleep apnea in non-stroke subjects. The investigators hypothesized that HFNC might be effective in stroke patients with dysphagia who needed nasogastric tube feeding and can not receive continuous positive airway pressure ventilation for obstructive sleep apnea.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ischemic stroke patients with dysphagia and obstructive sleep apnea who need nasogastric tube feedings
排除标准
- •congestive heart failure, unconsciousness, chronic obstructive pulmonary disease, intracranial hemorrhage or malignancy, and unstable medical and neurological conditions
- •central sleep apnea
结局指标
主要结局
apnea-hypopnea index
时间窗: once at polysomnography study night when receive high flow nasal cannula titration study
respiratory inductance plethysmography sum (RIPsum) without calibration to score apnea and hypopnea events (American Academy of Sleep Medicine alternative criteria)
oxyhemoglobin desaturation index
时间窗: once at polysomnography study night when receive high flow nasal cannula titration study
number of times per hour of sleep that the blood's oxygen saturation level drops by ≥ 3% from baseline
次要结局
- heart rate variability(baseline and 1 week after high flow nasal cannula therapy)
- pulse wave velocity(baseline and 1 week after high flow nasal cannula therapy)
研究者
CHEN,CHUNG YAO
Physician, associate professor, department of physical medicine and rehabilitation
Chang Gung Memorial Hospital