Viscoelastic Guided Goal Directed Resuscitation of Severely Injured Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Change in number of blood products utilized at 24 hours
研究概览
简要总结
This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of blood products, effects on coagulation and inflammatory mediators, and how these strategies affect post resuscitation adverse events.
详细描述
This is an open labeled study as the VE guided resuscitation will be based on the visible VE results. Aim 1 will compare the number of blood products utilized in each resuscitation strategy. Aim 2 will analyze the coagulation and inflammatory mediators in each resuscitation strategy to determine if there is a difference in the mechanism of coagulopathy. Aim 3 will determine if the different resuscitation strategies have an effect on post resuscitation adverse events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Trauma patient
- •MTP Activation
- •Only patients ≥ 14 years old
- •Alive at 31 mins after arrival in ED
排除标准
- •Transfer from OSH
- •Received CPR for more than 5 mins
- •Pregnant or Prisoner
- •Jehovah's witness
结局指标
主要结局
Change in number of blood products utilized at 24 hours
时间窗: 24 hours from time of randomization
Number of blood products utilized during that time frame will be recorded to determine if change in resuscitation strategies result in measurable differences
次要结局
- Change in coagulation profile(0 hours and 30 days)
- Change in inflammatory mediators(0 hours and 30 days)
- Changes in Resuscitation strategy-related adverse events(30 days after admission)