Evaluation of articular disc using MR-cartigram in asymptomatic and symptomatic temporomandibular disorders
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Diagnosis of early changes in the articular cartilage of TMJ in patients with TMJ disorders
研究概览
简要总结
Clinical evaluations and imaging of the temporomandibular joint are crucial for the diagnosis and management of temporomandibular disorders (TMD). MR imaging has recently been acknowledged as the gold standard imaging technique of choice in the investigation of TMJ dysfunction. The MR cartigram, a T2 mapping technique that analyses the structural components of articular cartilage and reveals biochemical parameters and structural changes by measuring the T2 transverse relaxation time, was utilised in earlier research to assess the early stages of cartilage tissue degradation. T2 mapping, also known as T2 value imaging, is a quantitative imaging technique that has been efficaciously used to identify degenerated cartilage in the knee joint, femoral condyle, and intervertebral disc by using a T2 relaxation time as an auxiliary indicator to reflect the water and collagen contents. T2 mapping was shown to be feasible in the temporomandibular joint. Our study is designed to diagnose the early changes in the cartilage in asymptomatic and symptomatic temporomandibular disorder patients using MR cartigram.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Group A Patients who are willing for the study 2.Patients above 18 years of age 3.Patients with temporomandibular joint disorders under RDC criteria is included.
- •Patients with symptoms of pain along with clicking, deviation during jaw movement, pain and difficulty in opening the mouth, pain in pre auricular area, and spreading to surrounding areas.
- •Group B 1.Patients who are willing for the study 2.Patients above 18 years of age 3.Patients with temporomandibular joint disorders under RDC criteria is included.
- •3.patients with temporomandibular disorders without pain but with symptoms of clicking, deviation while opening and closing the mouth, locking of the jaw while opening the mouth Group C
- •Patients who are willing for the study
- •Patients above 18 years of age 3.Healthy volunteers without any symptoms of temporomandibular joint disorders.
排除标准
- •Patients under 18 years of age
- •Pregnant and lactating patients
- •MRI is contraindicated in patients with pace makers, metallic implants, aneurysmal brain clips, metallic intra ocular foreign bodies, cochlear implants, claustrophobic patients.
- •Physically challenged and mentally retarded persons
- •Obese patients with more than 150 kgs who doesn’t fit in the MRI machine.
结局指标
主要结局
Diagnosis of early changes in the articular cartilage of TMJ in patients with TMJ disorders
时间窗: 4-8 weeks
次要结局
- Diagnosis of early changes in the articular cartilage of TMJ in TMJ disorder patients.(8 weeks)