Intravitreal Combination Therapy Using Triamcinolone and Bevacizumab Improves Vision in Patients With Retinal Vein Occlusion
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- BCVA
研究概览
简要总结
The aim of this pilot study was to investigate the effects of an intravitreal combination therapy using triamcinolone and bevacizumab in patients with retinal vein occlusion (RVO).
详细描述
This prospective study of a case series was conducted in 47 patients (n = 47 eyes; f/m: 21/26; mean age: 66.6 years) with ischemic central RVO (CRVO) (n = 15), non-ischemic CRVO (n = 7), or branch RVO (BRVO) (n = 25). A core pars plana vitrectomy with aspiration of 1.5 ml vitreous and infusion of balanced salt solution (BSS; 1 ml), 8 mg (0.4 ml) triamcinolone, and 1.25 mg (0.1 ml) bevacizumab was performed with a single sutureless sclerotomy and a 23 gauge probe tip. At baseline and follow-up, the best corrected visual acuity (BCVA; 6 m Snellen), and intraocular pressure (IOP; Goldmann tonometry), and central macular thickness (optical coherence tomography) were determined. In addition, the need for further treatment and adverse events were monitored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic central RVO (CRVO)
- •Non-ischemic CRVO
- •Branch RVO (BRVO)
排除标准
- •Visual deterioration due to acute or chronic inflammation
- •Post trauma
- •Macular edema of other origin
- •Intravitreal drug treatment within last 4 months
研究组 & 干预措施
ischemic CRVO
treatment was applied to this entity
干预措施: triamcinolone and bevacizumab (Drug)
non ischemic CRVO
treatment was applied to this entity
干预措施: triamcinolone and bevacizumab (Drug)
BRVO
treatment was applied to this entity
干预措施: triamcinolone and bevacizumab (Drug)
结局指标
主要结局
BCVA
时间窗: day of exam
次要结局
未报告次要终点
研究者
Michael Koss
PI
Johann Wolfgang Goethe University Hospital
