Pharmaco-therapeutic Evaluation of Different Parts (Leaf, Stem Bark, and Root Bark) of Shami (Prosopis cineraria (L.) Druce) in the Management of Dadru w.s.r. to Dermatophytosis.

The study entitled Pharmaco-therapeutic Evaluation of Different Parts (Leaf, Stem Bark and Root Bark) of Shami in the Management of Dadru focuses on exploring the therapeutic role of Shami in Dadru. In Ayurveda, Dadru is described as a Kshudra Kushtha, predominantly involving Pitta Kapha dosha with symptoms such as circular patches, itching, redness, and eruptions. Clinically, it corresponds to superficial fungal infections, largely caused by Trichophyton rubrum. Conventional antifungal therapies often face challenges such as recurrence and resistance, highlighting the need for safe, affordable, and effective alternatives.   Shami has been traditionally used for skin diseases and possesses antifungal potential, with prior in vitro studies suggesting activity against Trichophyton rubrum and Candida albicans. This research will undertake pharmacognostical, phytochemical, and MIC analyses of Shami’s leaf, root bark, and stem bark, followed by a randomized, single-blind, three arm clinical trial involving 120 patients. Topical creams of 20 percent extracts will be prepared and assessed based on the Dermatophytosis Area and Severity Index, clinical symptom scoring, and Dermatology Life Quality Index. The study aims to compare and establish the relative efficacy of different parts of Shami, thereby contributing evidence-based validation for its role in the management of Dadru.