Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Withdrawal symptoms
研究概览
简要总结
This project tests two hypotheses concerning the low smoking cessation rates in smokers with schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger and more sustained effects of smoking abstinence on negative mood and smoking urge than control smokers without psychiatric illness. The second hypothesis is that smokers with schizophrenia experience stronger reinforcing effects of a smoking lapse (i.e., more rewarding effects of smoking after a period of abstinence) than control smokers without psychiatric illness.
详细描述
In this study, smokers with schizophrenia and smokers without psychiatric illness participate in a nicotine preference task before and after a 3-day period of continuous smoking abstinence. The investigators will experimentally control abstinence by providing participants with high-value cash incentives contingent upon smoking abstinence verified with breath carbon monoxide levels. The investigators will measure nicotine withdrawal and smoking urge during the abstinence period. In the nicotine preference task, participants will make choices between nicotine-containing and denicotinized cigarette puffs to provide a measure of nicotine reinforcement, and the investigators will also measure the effects of smoking on mood. After the second nicotine preference task, participants will receive a small-value reinforcer if they continue to abstain for another day, and the investigators will measure time to the second lapse.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •cigarette smokers, 20-50 cigarettes per day
- •schizophrenia or no psychiatric illness
- •age 18 or older
- •male or female
排除标准
- •unstable symptoms or medication
- •not interested in quitting smoking within 6 months
结局指标
主要结局
Withdrawal symptoms
时间窗: 3 days
negative mood related to nicotine withdrawal
positive and negative mood
时间窗: before and after 3 days of abstinence
positive and negative mood scale
urge to smoke
时间窗: 3 days
craving for smoking
nicotine preference
时间窗: before and after 3 days of abstinence
choice for nicotine puffs versus denicotinized cigarette puffs
次要结局
- time to lapse(192 hours)
研究者
Jennifer Tidey
Associate Professor (Research)
Brown University