Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Cerebral Blood Volume (CBV)
研究概览
简要总结
- Generate a dynamic mapping of the distribution of iodine within the cerebral parenchyma in the patient suspected of acute ischemic disorder with the CT spectral scanner.
- Correlate the anomalies of iodine mapping to the other parameters acquired during the classic dynamic infusion phase to define the ischemic area (MTT higher and rCBV normal) versus infarcted zone (MTT higher and rCBV decreased)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms)
- •Age between 50 and 95 years
- •Weight: between 65 and 95 kg
排除标准
- •Documented or suspected allergy to IV iodinated contrast media
- •Renal impairment with creatinine clearance <60 ml / min
- •Hemorrhagic lesions or vascular abnormalities demonstrated on CT before contrast injection
研究组 & 干预措施
Stroke
Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms):Intervention 'spectral CT'
干预措施: spectral CT (Radiation)
结局指标
主要结局
Cerebral Blood Volume (CBV)
时间窗: from start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
CBV is measured in units of milliliters of blood per 100 g of brain and is defined as the volume of flowing blood for a given volume of brain.
Mean Transit Time (MTT)
时间窗: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
MTT is measured in seconds and defined as the average amount of time it takes blood to transit through the given volume of brain.
Cerebral Blood Flow (CBF)
时间窗: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
CBF is measured in units of milliliters of blood per 100 g of brain tissue per minute and is defined as the volume of flowing blood moving through a given volume of brain in a specific amount of time.
次要结局
未报告次要终点