Can the Betatrophin be a Reliable Marker of Insulin Resistance in Normal Weight and Overweight Women With Polycystic Ovary Syndrome?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- serum Betatrophin levels
研究概览
简要总结
This is an original study giving an information about the association body mass index, polycystic ovary syndrome and betatrophin.
详细描述
Introduction
Betatrophin is a protein hormone which has a significant role in glucose homeostasis and lipid metabolism. The aim of this study is to compare the levels of serum betatrophin in overweight and normal weight women with PCOS.
Material and Method: Thirty-five patients normal weight women with PCOS (BMI<25) and 38 obese women with PCOS (BMI≥25) were included in this prospective, cross-sectional study. Patients were selected according to Rotterdam criteria. Serum betatrophin levels were studied by ELISA method and then compared between these two groups besides the following additional parameters as waist circumference/hip circumference ratio, fasting blood glucose, 75 g OGTT (oral glucose tolerance test) results and HOMA-IR levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Polycystic ovary syndrome according to 2003 Rotterdam PCOS Consensus diagnostic criteria
- •Exclusion criteria
- •pregnancy,
- •an additional systemic disease (i.e.,hyperprolactinemia, thyroid dysfunction, liver or kidney diseases, cardiovascular disease, hyperlipidemia, type 1 or type 2 diabetes, chronic or acute infection within the previous 30 days),
- •morbid obesity,
- •the use of medications for contraception, androgen excess, hypertension, hyperglycemia or dyslipidemia at least 3 months before the study.
排除标准
- 未提供
结局指标
主要结局
serum Betatrophin levels
时间窗: 30 min
ng/L
次要结局
- 75 gr OGTT(oral glucose tolerance test)(2 hours)
- BMI (body mass index)(5 minute)
- Waist/hip ratio(5 min)
研究者
Hatice Akkaya
associate professor
Kayseri Education and Research Hospital