Comparison of Bolus Intravenous Lidocaine Administration With Continuous Intravenous Lidocaine Against Post-Extubation Cough Incidence in Post-Thyroidectomy Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Post-Extubation Cough Grade
研究概览
简要总结
The goal of this randomized controlled trial is to compare the effect of lidocaine bolus intravenous administration to lidocaine continuous intravenous administration in post thyroidectomy patients to observe the effect against post-extubation cough. The main questions it aims to answer are:
- Cough incidence on both groups
- Which method is preferable to reduce post-extubation cough incidence
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA class 1 and 2
- •Thyroidectomy patients in Hasan Sadikin Bandung Hospital
排除标准
- •Subjects' refusal
- •Had history of drug allergy, specifically lidaocaine
- •Had history of asthma or other lung diseases
- •Active smoker
- •History of arrhythmia
- •Bradycardia subjects (<60 beats per minute)
- •Pregnant people
- •Perioperative upper respiratory tract infusion
- •Routinely consume ACE inhibitor / bronchodilators / steroid
- •Renal dysfunction
- •Liver dysfunction
研究组 & 干预措施
Continuous Lidocaine Intravenous Infusion
Patients were given a loading dose of 1.5 mg/kgBW intravenous lidocaine for 10 minutes before induction of anesthesia using a syringe pump, followed by continuous intravenous administration of 1.5 mg/kgBW/hour lidocaine until 30 minutes before the end of the surgery (when the skin is being sutured by the surgeon) using a syringe pump. Continuous administration of lidocaine was prepared by the research team as 10 cc of 20 mg/cc lidocaine in a 10 cc syringe and 10 cc of 0.9% NaCl in a 10 cc syringe.
干预措施: Lidocaine IV (Drug)
Bolus Lidocaine Intravenous
Patients were given a loading dose of 1.5 mg/kgBW intravenous lidocaine for 10 minutes before induction of anesthesia using a syringe pump, followed by intravenous infusion of saline with the same volume until 30 minutes before the end of the surgery (when the skin is being sutured by the surgeon) using syringe pump.
干预措施: Lidocaine IV (Drug)
结局指标
主要结局
Post-Extubation Cough Grade
时间窗: 24 hours post operative
Cough graded according to the following criteria: Grade 0: no cough; Grade 1: mild, only 1 cough; Grade 2: moderate, \>1 cough lasting \<5 seconds; Grade 3: coughing heavily and continuously for \>5 seconds)
次要结局
- Number of participant experiencing tachycardia(24 hours perioperative)
- Number of participant experiencing hypertension(24 hours perioperative)
- Number of participant experiencing hypotension(24 hours perioperative)
- Number of participant experiencing bradycardia(24 hours perioperative)